What does endocrinology study?
The endocrine system and its hormones.
What are the two physiologic regulatory systems?
Endocrine system and Nervous system.
What is neuroendocrinology?
The branch of biology studying the interaction between the nervous and endocrine systems.
What do endocrine glands secrete?
Substances or hormones directly into the bloodstream.
How do exocrine glands function?
They secrete hormones into ducts leading to the external environment.
What characterizes the endocrine system?
Consists of ductless glands secreting hormones into the circulatory system.
What is the control method for endocrine glands?
Control of hormone synthesis rather than degradation.
What is the purpose of homeostatic control systems?
To maintain constant chemical composition of extracellular and intracellular fluids.
What is negative feedback?
An increase in product decreases system activity and production rate.
What is an example of negative feedback?
Body shivering in response to cold to return temperature to set point.
What is positive feedback?
An increase in product also increases system activity and production rate.
What is an example of positive feedback?
GnRH stimulates FSH or LH release, enhancing estrogen production.
What is the function of hormones?
To transfer information and instructions between cells.
What are the characteristics of hormones?
Produced by specific endocrine glands and act at target sites.
What are the functions of hormones?
Regulate ECF composition, metabolism, muscle contraction, and immune system.
What does the term 'hormon' mean in Greek?
To set in motion.
Which glands are part of the endocrine system?
Pituitary, Thyroid, Parathyroid, Adrenal, Pancreas, Reproductive, Thymus, Pineal.
What role do hormones play in growth and development?
Smooth sequential integration of growth and development.
What basic processes do hormones contribute to?
Reproduction, gamete production, nourishment of fetus and embryo.
What do hormones help maintain?
Homeostasis.
What is endocrine hormone delivery?
Secreted in one location and released into blood circulation.
What are ductless glands?
Glands that secrete hormones directly into the bloodstream.
What is paracrine hormone delivery?
Secreted by endocrine cells and released into interstitial space.
How do paracrine hormones affect adjacent cells?
They bind to specific receptors in adjacent cells.
What is autocrine hormone delivery?
Secreted by endocrine cells and binds to receptors on the cell of origin.
What is juxtacrine hormone delivery?
Secreted by endocrine cells and acts on adjacent cells by direct contact.
What is exocrine hormone delivery?
Secreted by endocrine cells and released into the gut lumen.
What is neurocrine hormone delivery?
Secreted by neurons and released into extracellular space.
How do neurocrine hormones affect nearby cells?
They bind to nearby cells and affect their function.
What is neuroendocrine hormone delivery?
Secreted by neurons and released from nerve endings.
What are releasing hormones?
Hormones from the hypothalamus that promote secretion of anterior pituitary hormones.
What are inhibitory hormones?
Hormones from the hypothalamus & GIT that suppress secretion of particular hormones.
What are tropic hormones?
Hormones that stimulate growth and activity of other endocrine glands.
What are effector hormones?
Hormones secreted by all endocrine glands targeting non-endocrine cells.
What are steroids derived from?
Cholesterol, a lipid molecule precursor.
Where are steroids produced?
Adrenal glands, ovaries, testes, and placenta.
What is the solubility of steroids?
Hydrophobic (water-insoluble).
What is the mechanism of action for steroids?
Free hormone interacts with intracellular receptors, binds to chromatin, produces mRNA.
What are biogenic amines derived from?
Amino acids.
What is an example of a biogenic amine?
Tyrosine.
What hormones are derived from tyrosine?
Thyroid hormones (T3, T4), adrenal hormones (epinephrine, norepinephrine).
How do epinephrine and norepinephrine act?
They interact with receptor sites on the cell membrane.
What are peptides and proteins synthesized from?
Synthesized and stored within the cell in secretory granules.
What is the solubility of peptides and proteins?
Water soluble and not bound to carrier proteins.
How do peptide hormones produce effects?
They interact with cell membrane receptors, activating second messenger systems.
What does PTH stand for?
Parathyroid Hormone
What is the mechanism of action of hormones like PTH?
Hormones interact with a cell membrane receptor, activating a second messenger system to affect cellular function.
What is the role of cell membrane receptors in hormone action?
They activate a second messenger system.
What does the second messenger system do in hormone action?
It affects cellular function.
What is neuroendocrinology?
The branch of biology studying the interaction between the nervous and endocrine systems.
How do exocrine glands function?
They secrete hormones into ducts leading to the external environment.
What characterizes the endocrine system?
Consists of ductless glands secreting hormones into the circulatory system.
What is the control method for endocrine glands?
Control of hormone synthesis rather than degradation.
What is the purpose of homeostatic control systems?
To maintain constant chemical composition of extracellular and intracellular fluids.
What is an example of negative feedback?
Body shivering in response to cold to return temperature to set point.
What is positive feedback?
An increase in product also increases system activity and production rate.
What is an example of positive feedback?
GnRH stimulates FSH or LH release, enhancing estrogen production.
What are the characteristics of hormones?
Produced by specific endocrine glands and act at target sites.
What are the functions of hormones?
Regulate ECF composition, metabolism, muscle contraction, and immune system.
Which glands are part of the endocrine system?
Pituitary, Thyroid, Parathyroid, Adrenal, Pancreas, Reproductive, Thymus, Pineal.
What role do hormones play in growth and development?
Smooth sequential integration of growth and development.
What basic processes do hormones contribute to?
Reproduction, gamete production, nourishment of fetus and embryo.
What is paracrine hormone delivery?
Secreted by endocrine cells and released into interstitial space.
What is autocrine hormone delivery?
Secreted by endocrine cells and binds to receptors on the cell of origin.
What is juxtacrine hormone delivery?
Secreted by endocrine cells and acts on adjacent cells by direct contact.
How do neurocrine hormones affect nearby cells?
They bind to nearby cells and affect their function.
What are releasing hormones?
Hormones from the hypothalamus that promote secretion of anterior pituitary hormones.
What are inhibitory hormones?
Hormones from the hypothalamus & GIT that suppress secretion of particular hormones.
What are effector hormones?
Hormones secreted by all endocrine glands targeting non-endocrine cells.
What is the mechanism of action for steroids?
Free hormone interacts with intracellular receptors, binds to chromatin, produces mRNA.
What hormones are derived from tyrosine?
Thyroid hormones (T3, T4), adrenal hormones (epinephrine, norepinephrine).
What are peptides and proteins synthesized from?
Synthesized and stored within the cell in secretory granules.
How do peptide hormones produce effects?
They interact with cell membrane receptors, activating second messenger systems.
What is the mechanism of action of hormones like PTH?
Hormones interact with a cell membrane receptor, activating a second messenger system to affect cellular function.
What is the role of cell membrane receptors in hormone action?
They activate a second messenger system.
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