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Flashcards in this deck (3)

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  • What can a mutation of an amino acid in the active site of a molecular target do?

    Can alter the binding of a ligand to the target

    Always reduces the volume of a binding pocket

    Never affects the binding of a ligand to the target

    Always increases the polarity of a binding pocket

    biochemistry mutations
  • What is the most reliable measure of a drug's bioavailability?

    Rate of first-pass metabolism of the drug

    Area under the plasma concentration-time curve

    Urinary levels of the drug 1 hour after administration

    Blood levels of the drug 1 hour after administration

    pharmacology bioavailability
  • What does the word 'open' mean in the one compartment open model?

    Unidirectional input and output

    Easy absorption

    The drug easily enters

    The drug readily mixes with the blood

    pharmacokinetics models