Flashcards in this deck (18)

• According to MCB.16.2, students should recognize the molecular components of cell-cell and cell-matrix interactions.
  learningobjectives molecularcomponents cellinteraction
• MCB.16.3 emphasizes the importance of matrix metalloproteinases in regulating cell adhesion.
  learningobjectives metalloproteinases celladhesion
• In MCB.16.4, students should differentiate the functions of extracellular matrix components, focusing on collagen, laminin, and elastin.
  learningobjectives extracellularmatrix components
• The reading assignment includes Molecular Biology of the Cell by Alberts, B. et al., 4th edition.
  readingassignment molecularbiology alberts
• Chapter 19 discusses Cell Junctions, including occluding junctions and anchoring junctions.
  readingassignment celljunctions chapter19
• Adherens junctions connect bundles of actin filaments from cell to cell.
  celljunctions adherensjunctions actin
• Desmosomes connect intermediate filaments from cell to cell.
  celljunctions desmosomes intermediatefilaments
• Gap junctions allow small molecules to pass directly from cell to cell.
  celljunctions gapjunctions molecules
• Cadherins mediate Ca2+-dependent cell-cell adhesion.
  celladhesion cadherins calcium
• Selectins mediate transient cell-cell adhesions in the bloodstream.
  celladhesion selectins bloodstream
• Integrins are involved in anchoring junctions that bind cells to the extracellular matrix.
  celljunctions integrins extracellularmatrix
• Glycosaminoglycan (GAG) chains occupy large amounts of space and form hydrated gels.
  extracellularmatrix gag hydratedgels
• Collagens are the major proteins of the extracellular matrix.
  extracellularmatrix collagens proteins
• Elastin gives tissues their elasticity.
  extracellularmatrix elastin elasticity
• Fibronectin exists in both soluble and fibrillar forms.
  extracellularmatrix fibronectin forms
• The basal laminae are composed mainly of Type IV collagen, laminin, and a heparan sulfate proteoglycan.
  extracellularmatrix basallaminae proteoglycan
• The extracellular matrix can influence cell shape, cell survival, and cell proliferation.
  extracellularmatrix cells influence
• The controlled degradation of matrix components helps cells migrate.
  extracellularmatrix degradation migration