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What is the primary definition of the AANA Code of Ethics?
It outlines expected behaviors for individuals who are part of the CRNA profession.
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In the context of clinical practice, what are Standards of Care?
A set of rules or minimum requirements for clinical practice that ensures high quality patient care.
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How are Standards of Care determined?
By individual hospital policies
By patient preference
By government decree only
By consensus and approval of recognized authoritative body
How are Standards of Care determined?
By individual hospital policies
By patient preference
By government decree only
By consensus and approval of recognized authoritative body
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When can Standards of Care be modified?
Only under unusual circumstances, such as extreme emergencies or unavailability of equipment.
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What is the fundamental difference between Standards of Care and Practice Guidelines?

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AANA Standard 1 focuses on _______, emphasizing the respect for the patient's _______.
AANA Standard 1 focuses on Patient Rights, emphasizing the respect for the patient's autonomy, dignity, and privacy.
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AANA Standard 2 pertains to _______, which involves documenting the patient's general health, _______.
AANA Standard 2 pertains to Pre-anesthesia Patient Assessment and Evaluation, which involves documenting the patient's general health, allergies, medication history, pre existing conditions, anesthesia history, and relevant diagnostic tests.
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What documentation is required under Standard 4 regarding informed consent?
Obtain and document or verify that the patient or legal representative has given informed consent for planned anesthesia care or related services.
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What is the frequency for documenting blood pressure, heart rate, and respiration during all anesthetics?
At least every five minutes.
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According to Standard 6, how should anesthesia equipment be managed prior to each use?
Verify the function of anesthesia equipment prior to each anesthetic.
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For patient ventilation, confirm intubation of the trachea or placement of airway devices by _______, _______, and _______.
For patient ventilation, confirm intubation of the trachea or placement of airway devices by auscultation, chest excursion, and confirmation of expired carbon dioxide.
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What safety measures should be taken regarding physiological monitoring device alarms?
Ensure variable pitch and threshold alarms are turned on and audible.
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What is the primary responsibility of a CRNA when transitioning patient care to another professional?
Evaluate the patient's status and determine when it is appropriate to transfer responsibility, while communicating essential information for continuity of care.
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What is the main goal of operating anesthesia equipment as described in Standard 6?
To maximize anesthesia output
To minimize the risk of fire, explosion, electrical shock, and equipment malfunction
To expedite patient recovery time
To reduce equipment maintenance costs
What is the main goal of operating anesthesia equipment as described in Standard 6?
To maximize anesthesia output
To minimize the risk of fire, explosion, electrical shock, and equipment malfunction
To expedite patient recovery time
To reduce equipment maintenance costs
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What is the ethical principle of Beneficence?
The obligation to do good.
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Define negligence in the context of professional practice.
Medical malpractice is a form of professional negligence. 
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What are the four required elements of proof for a plaintiff in a negligence case?
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The _______ doctrine translates to _______, where the _______ shifts from the plaintiff to the defendant.
The Res ipsa loquitur doctrine translates to the thing speaks for itself, where the burden of proof of causation shifts from the plaintiff to the defendant.
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When should a patient be informed of a medical risk?
Only when the risk is low and severity is great
Only when the severity is minor
Only when the patient specifically asks for details
When the risk is statistically high
When should a patient be informed of a medical risk?
Only when the risk is low and severity is great
Only when the severity is minor
Only when the patient specifically asks for details
When the risk is statistically high
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What are the two types of Advanced Directives?
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What is the function of a Medical Durable Power of Attorney?
It designates another person to make health care decisions for a patient if they become incompetent or unable to make such decisions themselves.
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What is the classification for a Level 5 surgical urgency?
Within 24 hours.
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What is an elective surgical procedure?
A procedure planned and scheduled in advance with no urgency.
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What does a patient's physical and history assessment allow for during anesthesia planning?
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Which herbal supplement use is noted as often overlooked?
Herbal supplements, which are used by up to 30% of the US population.
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What are three examples of patient-related anesthetic history complications?
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What condition might explain a prolonged duration of muscle relaxant effect in a patient?
Pseudocholinesterase deficiency.
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For NPO status, it is important to document the _______ and the _______.
For NPO status, it is important to document the last solid food, content and time and the last liquid intake.
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When assessing airway requirements, what does the airway assessment allow for?
Planning for masking, intubation, or alternate airway modalities
Determining the patient's ASA physical status
Calculating the required dosage of muscle relaxants
Scheduling the procedure urgency level
When assessing airway requirements, what does the airway assessment allow for?
Planning for masking, intubation, or alternate airway modalities
Determining the patient's ASA physical status
Calculating the required dosage of muscle relaxants
Scheduling the procedure urgency level
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What is the minimum fasting period required before surgery for clear liquids, such as water, black coffee, or pulp-free fruit juice?
2 hours
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How long should a patient fast before surgery after consuming breast milk?
4 hours
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What is the required minimum fasting period for nonhuman milk, such as infant formula?
6 hours
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What is the required minimum fasting period for a light meal containing toast and clear liquids?
6 hours
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What is the minimum fasting period for a regular or heavy meal, including fried or fatty food?
8 hours
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In the ASA Physical Status Classification system, what does the addition of an 'E' denote?
Emergency surgery
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According to the ASA Physical Status Classification, how is an 'ASA 1' patient described?
Healthy patients
Declared brain-dead patient
Severe disease process
Moribund patient
According to the ASA Physical Status Classification, how is an 'ASA 1' patient described?
Healthy patients
Declared brain-dead patient
Severe disease process
Moribund patient
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Which ASA classification level describes a patient who is moribund and not expected to survive 24 hours with or without an operation?
ASA 6
ASA 5
ASA 3
ASA 4
Which ASA classification level describes a patient who is moribund and not expected to survive 24 hours with or without an operation?
ASA 6
ASA 5
ASA 3
ASA 4
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An emergency surgery is defined as existing when delay in treatment would lead to a significant increase in the _______.
An emergency surgery is defined as existing when delay in treatment would lead to a significant increase in the threat to life or body part.
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What is the clinical significance of an inability to achieve 4 METs?
It is associated with increased perioperative risk.
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What is the formal definition of 1 MET?
It is defined as the energy used when resting or sitting still, equal to \(3.5 \text{ mL O}_2 / \text{kg} / \text{min}\).
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Which six independent risk factors are included in the Revised Cardiac Risk Index (RCRI)?
The RCRI uses the following six independent predictors: - Ischemic heart disease - Congestive heart failure - Cerebrovascular disease - Diabetes mellitus treated with insulin - Serum creatinine \(> 2 \text{ mg/dL}\) - High-risk surgery (intraperitoneal, intrathoracic, or suprainguinal vascular)
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What is the Revised Cardiac Risk Index (RCRI) primarily used for?
To assess metabolic equivalents
To measure long-term mortality
To assign perioperative cardiac risk
To diagnose coronary artery disease
What is the Revised Cardiac Risk Index (RCRI) primarily used for?
To assess metabolic equivalents
To measure long-term mortality
To assign perioperative cardiac risk
To diagnose coronary artery disease
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Chronic hypertension affects autoregulation curves by causing a _______ and a _______.
Chronic hypertension affects autoregulation curves by causing a shift to the right and a narrowing of the plateau.
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What are the common symptoms of unstable cardiac disease that require further evaluation?
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What activities require an energy expenditure of 4 METs according to the estimation table?

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What are the common symptoms of aortic stenosis (AS) or its disease progression?
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What is the recommended interval for interrogating a patient's pacemaker?
Every 12 months
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What is the recommended interval for interrogating a patient's ICD?
Every 6 months
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For patients with coronary artery stents, the delay for elective surgery should be _______ days for bare metal stents (BMS) and _______ days for drug-eluting stents (DES).
For patients with coronary artery stents, the delay for elective surgery should be 30 days for bare metal stents (BMS) and 365 days for drug-eluting stents (DES).
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What happens when a magnet is placed over an implanted cardioverter-defibrillator (ICD)?
It inhibits arrhythmia detection.
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How many risk factors for CAD indicate an intermediate risk level for pre-operative testing?
0-1
2
3
4
How many risk factors for CAD indicate an intermediate risk level for pre-operative testing?
0-1
2
3
4
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What does a systolic murmur in the right second intercostal space indicate?
Aortic stenosis
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According to AHA/ACC guidelines, preoperative echocardiography is required for moderate to severe valvular stenosis or regurgitation if no studies have been performed within _______ or if there is worsening clinical status.
According to AHA/ACC guidelines, preoperative echocardiography is required for moderate to severe valvular stenosis or regurgitation if no studies have been performed within 1 year or if there is worsening clinical status.
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What are the components of the STOP-Bang screening tool for obstructive sleep apnea?
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What is considered a high-risk score on the STOP-Bang screening tool?
4+
2+
0-3
5+
What is considered a high-risk score on the STOP-Bang screening tool?
4+
2+
0-3
5+
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What happens to the body 24-48 hours after smoking cessation?
- Decrease in nicotine levels
- Decrease in CV (cardiovascular) effects
- Decrease in carbon monoxide levels
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What improvements occur 6-8 weeks after smoking cessation?
- Improvement in ciliary function
- Decrease in mucus production
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Long-term benefits of smoking cessation include an addition of _______ life expectancy and a reduced risk of _______ and _______.
Long-term benefits of smoking cessation include an addition of 6 to 8 years life expectancy and a reduced risk of lung cancer and heart disease.
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What are three common GI and hepatic conditions assessed in a preoperative history?
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What conditions are commonly noted in a renal assessment?
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What are three blood-related conditions relevant to a hematologic assessment?
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What is the normal measurement for the interincisor gap (IIG) during a preoperative airway exam?
Normal = 3 finger breadths or 5 cm
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What is the normal thyromental distance (TMD) measurement?
Normal = 3 finger breadths or 6.5 cm
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For the airway exam, _______ extension is necessary to align the axes and visualize the _______.
For the airway exam, c-spine extension is necessary to align the axes and visualize the vocal cords.
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During an airway exam, the presence of ridges from the patient's teeth on the tongue is a sign that the _______ does not have much room.
During an airway exam, the presence of ridges from the patient's teeth on the tongue is a sign that the tongue does not have much room.
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What does the upper lip bite test signify during an airway exam?
Difficult intubation
Macroglossia
Reduced neck extension
Good mobility
What does the upper lip bite test signify during an airway exam?
Difficult intubation
Macroglossia
Reduced neck extension
Good mobility
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Why is macroglossia problematic during intubation?
The tongue has to be displaced, and the larger the tongue, the more difficult it is to gain control of it.
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The preoperative physical exam includes assessing _______, _______, _______, and _______.
The preoperative physical exam includes assessing vital signs, height/weight/BMI, general appearance, and breath sounds.
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What structures are visible in a Mallampati Class 1 airway? 
Full view of the soft palate, uvula, and tonsillar pillars.
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Which Mallampati class is characterized by the soft palate and upper portion of the uvula being visible?
Class 2.
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What is the visibility expectation for a Mallampati Class 3 airway?
Just the soft palate is visible; the uvula is not.
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What structure is visible in a Mallampati Class 4 airway?
Only the hard palate.
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Predictors of difficult intubation include an interincisor distance of less than _______.
Predictors of difficult intubation include an interincisor distance of less than 3 cm.
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A patient with a 'thick neck' is a predictor of difficult intubation if the circumference is greater than _______ in males or _______ in females.
A patient with a 'thick neck' is a predictor of difficult intubation if the circumference is greater than 17 in in males or 16 in in females.
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Which of the following is considered a predictor of difficult mask ventilation?
Long neck
Young age
Obesity
High range of motion of C-spine
Which of the following is considered a predictor of difficult mask ventilation?
Long neck
Young age
Obesity
High range of motion of C-spine
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Besides obesity and male gender, what is another anatomical predictor of difficult mask ventilation related to the face?
Beard.
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According to the 2012 ASA Practice Advisory, how should pre-op tests be ordered for asymptomatic patients?
They should only be ordered after considering information obtained from the medical record, H&P, and the type or invasiveness of the planned procedure and anesthesia.
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What are the clinical indications for ordering a preoperative CBC?
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What factors should the decision to order T&S (Type and Screen) or T&C (Type and Crossmatch) be based on?
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For preoperative blood conservation, strategies should be considered to minimize the use of _______.
For preoperative blood conservation, strategies should be considered to minimize the use of allogeneic blood.
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How long prior to the date of surgery (DOS) should NSAIDs be held?
2-7 days prior to DOS.
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How long prior to the date of surgery (DOS) should Coumadin be held?
5 days prior to DOS.
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Which of the following medications should be continued before surgery?
GLP-1 Agonists
Statins
Diuretics
NSAIDs
Which of the following medications should be continued before surgery?
GLP-1 Agonists
Statins
Diuretics
NSAIDs
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What is the recommended pre-operative hold time for St. John's Wort?
At least 5 days prior to the date of surgery.
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What is the recommended pre-operative hold time for Enbrel?
2 weeks prior to surgery.
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How should high-risk antiplatelet therapy be managed before surgery?
Hold clopidogrel and continue ASA.
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What is the upper limit for glucose control in Type 1 diabetic patients undergoing surgery?
Less than 200 mg/dL
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When should antibiotics be administered in relation to the incision?
Within 1 hour prior to incision
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What is the recommended antibiotic strategy if a procedure is prolonged beyond two half-lives?
Redose the antibiotic
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What dosage adjustment is required for morbidly obese patients receiving antibiotic prophylaxis?
Twice the dose of normal weight patients
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Which antibiotics should be used for surgical prophylaxis in patients with a penicillin allergy?
Vancomycin or clindamycin
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What criteria define Mendelson's syndrome?
Volume > 25 mL and pH < 2.5
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What is the most significant ranked risk factor for pulmonary aspiration?
Obesity
Emergency surgery
GERD
Opioid use
What is the most significant ranked risk factor for pulmonary aspiration?
Obesity
Emergency surgery
GERD
Opioid use
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Routine pharmacologic prophylaxis for aspiration is _______ in otherwise healthy patients with no risk factors undergoing elective procedures.
Routine pharmacologic prophylaxis for aspiration is not recommended in otherwise healthy patients with no risk factors undergoing elective procedures.
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What is the primary clinical benefit of administering Sodium Citrate prior to anesthesia?
It minimizes the risk of lung injury by increasing the pH of gastric fluid.
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Why should Metoclopramide be avoided in patients with a suspected bowel obstruction?
Because it increases gastric motility, which could precipitate complications like bowel perforation.
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Which type of antacid is contraindicated for use due to the risk of serious pulmonary sequelae if aspirated?
Nonparticulate antacids (e.g., Sodium Citrate)
Histamine-2 receptor antagonists
Proton pump inhibitors
Particulate antacids (e.g., Tums, Rolaids)
Which type of antacid is contraindicated for use due to the risk of serious pulmonary sequelae if aspirated?
Nonparticulate antacids (e.g., Sodium Citrate)
Histamine-2 receptor antagonists
Proton pump inhibitors
Particulate antacids (e.g., Tums, Rolaids)
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How do Histamine-2 receptor antagonists affect gastric secretions?
They decrease gastric volume and acidity by blocking the ability of histamine to induce secretion of gastric fluid with a high \(H^+\) concentration.
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Among H2 receptor antagonists, _______ has the longest duration of action, typically lasting _______ hours.
Among H2 receptor antagonists, Famotidine has the longest duration of action, typically lasting 10-12 hours.
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What is the primary mechanism of action for Proton Pump Inhibitors (PPIs)?
They suppress gastric acid secretion by binding to the proton pump of the parietal cells.
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List three primary goals of administering pre-operative medication.
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Extreme caution should be used with pre-op sedation in patients with _______, _______, or _______.

Extreme caution should be used with pre-op sedation in patients with intracranial pathology, severe pulmonary disease, or hypovolemia.
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What is the primary action of Dexmedetomidine as an alpha-2 agonist?
It produces sedation and attenuates the sympathetic nervous system response to stimulation.
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What is a characteristic side effect of opioid administration regarding gastrointestinal function?
Delayed gastric emptying.
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Which anticholinergic medication listed is known to be more potent than Atropine for antisialagogue effects?
Glycopyrrolate.
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Which drug is categorized as a Quaternary Amine anticholinergic that does not easily cross the blood-brain barrier?
Glycopyrrolate
Atropine
Midazolam
Scopolamine
Which drug is categorized as a Quaternary Amine anticholinergic that does not easily cross the blood-brain barrier?
Glycopyrrolate
Atropine
Midazolam
Scopolamine
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According to the table comparing anticholinergics, which agent has the strongest sedative and amnesic effects?
Scopolamine
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The most common benzodiazepine used in anesthetic practice is _______, which is valued for its _______.
The most common benzodiazepine used in anesthetic practice is Midazolam, which is valued for its rapid onset and recovery.
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Why is the routine use of anticholinergics considered uncommon?
Due to side effects such as CNS toxicity, tachycardia, pupil dilation, relaxation of the lower esophageal sphincter, inhibition of sweating, and thickened secretions.
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What are the five main risk factors for PONV in adults? 
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Which of the following is a recommended strategy to mitigate PONV?
Routine use of nitrous oxide
Avoidance of hydration
Increased use of volatile anesthetics
Use of regional anesthesia
Which of the following is a recommended strategy to mitigate PONV?
Routine use of nitrous oxide
Avoidance of hydration
Increased use of volatile anesthetics
Use of regional anesthesia
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For patients with _______ risk factors for PONV, give _______ agents; for patients with _______ risk factors, give _______ agents.
For patients with 1-2 risk factors for PONV, give 2 agents; for patients with > 2 risk factors, give 3-4 agents.
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What is the recommended newer stress-dose steroid treatment for the first day of surgery?
100 mg hydrocortisone IV followed by 50 mg IV q8 hours.
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Potential adverse effects of stress-dose steroid treatment include: - _______ - _______ - _______ - _______ - _______
Potential adverse effects of stress-dose steroid treatment include: - Hypertension - Hyperglycemia - Increased risk of infection - Delayed wound healing - Electrolyte disturbance/Fluid retention
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What is the typical prophylactic combination used against allergic reactions?
H1 (Benadryl) + H2 (Zantac/Pepcid) + Steroid (hydrocortisone)
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Pretreatment with a combination of _______ is more effective than _______ alone.
Pretreatment with a combination of H1 and H2 antagonists is more effective than H1 antagonists alone.
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What are the five major goals of general anesthesia?
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During which stage of Guedel's anesthesia is 'Excitement' observed?
Stage 3
Stage 2
Stage 4
Stage 1
During which stage of Guedel's anesthesia is 'Excitement' observed?
Stage 3
Stage 2
Stage 4
Stage 1
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What are the pupil characteristics in Guedel's Stage 4 anesthesia?
Dilated and unreactive
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In Guedel's classification, Stage 1 is also known as the _______ or _______.
In Guedel's classification, Stage 1 is also known as the Induction Period or Analgesia.
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What is the primary characteristic of Guedel's Stage 4 anesthesia?
Anesthetic Crisis (breathing stops to death)
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What occurs during Plane 4 of Guedel's Stage 3 (Surgical Anesthesia)?
Complete intercostal paralysis to diaphragmatic paralysis, apnea, and loss of respiratory effort.
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In Guedel's Stage 3, Plane 3, what happens to the light reflex?
It is abolished.
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What are the physiological signs associated with Guedel's Stage 2 (Excitement)?
- Irregular respiration
- Breath holding
- Pupillary dilation
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What mnemonic is used for pre-induction anesthesia tasks?
MS. MAIDS
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What does each letter in the 'MS. MAIDS' mnemonic stand for in the context of pre-induction anesthesia tasks?
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The components of the _______ mnemonic are: - _______ - _______ - _______ - _______ - _______ - _______ - _______
The components of the MS. MAIDS mnemonic are: - Machine - Suction - Monitors - Airway - IV access - Drugs - Special
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What is the primary goal of administering pre-induction medications?
Blunt hemodynamic (HD) response to direct laryngoscopy (DL).
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What are two ways to achieve preoxygenation for anesthesia induction?
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How is loss of consciousness (LOC) assessed during pre-induction?
By checking the lash reflex, then taping the eyes.
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List four methods to verify endotracheal tube (ETT) placement.
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What is a standard component of pre-induction documentation?
Discharge summary
Informed consent obtained
Post-operative pain scale
Patient insurance verification
What is a standard component of pre-induction documentation?
Discharge summary
Informed consent obtained
Post-operative pain scale
Patient insurance verification
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What is the primary goal of Rapid Sequence Induction (RSI)?
To minimize aspiration risk.
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What is the clinical endpoint for preoxygenation in RSI?
\(ETO_2 > 90\%\)
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When should cricoid pressure be applied and released during RSI?
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The Cormack-Lehane Grade 1 view indicates a _______ view of the glottic opening.
The Cormack-Lehane Grade 1 view indicates a complete or nearly complete view of the glottic opening.
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Which of the following is a contraindication to the use of succinylcholine (SCh) for RSI?
Full stomach
Pregnancy
Malignant hyperthermia (MH) susceptibility
GERD
Which of the following is a contraindication to the use of succinylcholine (SCh) for RSI?
Full stomach
Pregnancy
Malignant hyperthermia (MH) susceptibility
GERD
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Based on the Cormack-Lehane scale, what is visible in a Grade 3 view?
Epiglottis only.
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What is the definition of fasciculations seen with succinylcholine induction?
SCh-induced involuntary muscle contractions.
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Using the provided Cormack-Lehane grading scale illustration, which grade displays only the soft palate?
Grade 4
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What are some clinical indications for using Total Intravenous Anesthesia (TIVA)?
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What categories of drugs are commonly used in Balanced Anesthesia?
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What are the minimum recording intervals for vital signs (BP, HR, RR) during maintenance of anesthesia?
Every 5 minutes
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What specific patient safety documentation must occur every 30 minutes regarding body position?
Documentation of the assessment of position changes.
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Intraoperative documentation of _______ (such as cardiac arrest, anaphylactic reaction, difficult airway, or EKG changes) usually requires a separate note in the patient's chart.
Intraoperative documentation of critical events (such as cardiac arrest, anaphylactic reaction, difficult airway, or EKG changes) usually requires a separate note in the patient's chart.
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Which of the following monitoring parameters is required to be documented at a minimum interval of every 15 minutes?
BP, HR, RR
Rate, Vt, PIP, PEEP
O2, N2O, or air
SaO2, FiO2, ETCO2
Which of the following monitoring parameters is required to be documented at a minimum interval of every 15 minutes?
BP, HR, RR
Rate, Vt, PIP, PEEP
O2, N2O, or air
SaO2, FiO2, ETCO2
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Regarding the surgical time-out, what items are included in the verification checklist?
- Patient identified
- Procedure confirmed
- Consent / H&P
- Site marking visible
- Diagnostics / images available
- Allergies verified
- Antibiotics verified
- Beta blocker verified
- Implants verified
- Blood verified
- DVT prophylaxis verified
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What clinical signs are associated with 'Light Anesthesia' when Neuromuscular Blocking Drugs (NMBD) are present?
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What are the cardiovascular effects of excessive 'deep anesthesia'?
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Which of the following is considered a patient group less suited for deep extubation?
Obese patients
Patients with no history of aspiration
Patients with low BMI
Patients with high tidal volume
Which of the following is considered a patient group less suited for deep extubation?
Obese patients
Patients with no history of aspiration
Patients with low BMI
Patients with high tidal volume
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The requirements for awake extubation include: - Breathing frequency < _______ breaths/min - Maximum inspiratory pressure < _______ cm \(H_2O\) - Vital capacity > _______ mL/kg - Tidal volume > _______ mL/kg
The requirements for awake extubation include: - Breathing frequency < 30 breaths/min - Maximum inspiratory pressure < -20 cm \(H_2O\) - Vital capacity > 15 mL/kg - Tidal volume > 6 mL/kg
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According to the comparative table, what is a primary 'Con' of awake extubation?
Increased coughing risk. 
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What does a deep extubation attempt to avoid?
Coughing and bucking.
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For deep extubation, the ETT is removed _______ and _______.
For deep extubation, the ETT is removed prior to wake up and prior to return of upper airway reflexes.
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List the three items that must be verbally confirmed by the surgeon, anesthesia professional, and nurse before skin incision.
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What is the Aldrete score required to meet discharge criteria?
9-10
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According to the Aldrete Scoring system, what oxygen saturation value indicates a score of 2?
\(SpO_2 > 92\%\) on RA
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What blood pressure criteria is needed for a score of 2 in the circulation category of the Aldrete score?
BP within \(20\text{ mmHg}\) of preanesthetic value (min SBP = \(90\text{ mmHg}\))
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For the consciousness category of the Aldrete score, a patient who is _______ receives a score of 2, while a patient who is _______ receives a score of 1.
For the consciousness category of the Aldrete score, a patient who is fully awake receives a score of 2, while a patient who is arousable to voice receives a score of 1.
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What is the score for a patient who is apneic in the respiration category of the Aldrete scoring system?
0
3
2
1
What is the score for a patient who is apneic in the respiration category of the Aldrete scoring system?
0
3
2
1
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When is the anesthesia end time documented?
When care is transferred to PACU/ICU
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In the context of follow-up post-op notes, how often should inpatients be seen after discharge from PACU?
At least once within 48 hours
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What elements should be included in a PACU handoff?
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What is the leading cause of anesthesia-related malpractice claims?
Death (30%)
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Name three causes of severe hypoxemia in the context of anesthesia. 
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What are three common causes of reduced cardiac output leading to cerebral ischemia under anesthesia? 
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The psychological consequences of anesthesia awareness can include _______, _______, and _______.
The psychological consequences of anesthesia awareness can include sleep disturbances, work & social impairment, and PTSD.
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List four risk factors associated with anesthesia awareness.
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What are three pharmacological or monitoring strategies used to mitigate the risk of anesthesia awareness?
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What is the most common reported eye injury related to anesthesia?
Corneal abrasion.
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What are three causes of corneal abrasion during anesthesia?
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Which surgical positions or procedures are risk factors for ischemic optic neuropathy?
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What are the causes of central retinal artery occlusion?
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Mendelson's syndrome is a type of chemical pneumonitis caused by the aspiration of gastric contents with a pH of less than _______ and a volume of _______ or greater.
Mendelson's syndrome is a type of chemical pneumonitis caused by the aspiration of gastric contents with a pH of less than 2.5 and a volume of 0.3 ml/kg or greater.
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What are the prevention strategies for Mendelson's syndrome?
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What is the primary genetic defect associated with malignant hyperthermia?
A defect in the genes coding for ryanodine receptors (RYR1).
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What classes of agents are known to trigger malignant hyperthermia?
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What are the earliest clinical signs of malignant hyperthermia?
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Malignant hyperthermia is inherited in an _______ pattern, meaning that _______ defective gene is needed for the disease to manifest.
Malignant hyperthermia is inherited in an autosomal dominant pattern, meaning that one defective gene is needed for the disease to manifest.
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What is a major consequence of sustained hypermetabolism in malignant hyperthermia related to muscle cell breakdown?
Decrease in core temperature
Decreased \(ETCO_2\) levels
Release of myoglobin, \(K^+\), and CK
Improved muscle oxygenation
What is a major consequence of sustained hypermetabolism in malignant hyperthermia related to muscle cell breakdown?
Decrease in core temperature
Decreased \(ETCO_2\) levels
Release of myoglobin, \(K^+\), and CK
Improved muscle oxygenation
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What physiological event occurs when triggering agents react with RYR1 receptors, initiating a hypermetabolic state?
Uncontrolled \(Ca^{2+}\) release from the sarcoplasmic reticulum into the myoplasm.
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What condition occurs if the body temperature reaches or exceeds \(41^{\circ} C\) during a malignant hyperthermia crisis?
Death usually due to DIC (disseminated intravascular coagulation).
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What are two specific musculoskeletal complications resulting from rhabdomyolysis in malignant hyperthermia?
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What is the mechanism of action of dantrolene?
It is a specific RYR1 receptor antagonist that prevents \(Ca^{2+}\) release from the SR and RYR1/DHP receptor coupling.
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What is the initial recommended dose of dantrolene for the treatment of malignant hyperthermia?
\(2.5\text{ mg/kg}\)
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Which of the following is true regarding the new formulation of dantrolene (Ryanodex) compared to the original (Dantrium)?
It is 150 times more concentrated.
It takes 860 seconds to mix.
It requires 60 ml of sterile water.
It is less expensive than the original formulation.
Which of the following is true regarding the new formulation of dantrolene (Ryanodex) compared to the original (Dantrium)?
It is 150 times more concentrated.
It takes 860 seconds to mix.
It requires 60 ml of sterile water.
It is less expensive than the original formulation.
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Delays in treatment are associated with _______ rates of complications and death in MH-related cases.
Delays in treatment are associated with high rates of complications and death in MH-related cases.
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What are the three main categories of causes for Neuroleptic Malignant Syndrome?
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How do NMS and MH compare regarding inheritance and onset time?
NMS is not inherited and takes 24-72 hours or several weeks to develop. MH is inherited and has early onset within minutes.
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Which drug is used as a dopaminergic agonist for the treatment of Neuroleptic Malignant Syndrome?
Bromocriptine
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Which of the following is a symptom of Neuroleptic Malignant Syndrome?
Bradycardia
Muscle rigidity
Hypothermia
Increased dopamine activity
Which of the following is a symptom of Neuroleptic Malignant Syndrome?
Bradycardia
Muscle rigidity
Hypothermia
Increased dopamine activity
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What three myopathic disorders are associated with susceptibility to malignant hyperthermia?
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What percentage of patients with masseter muscle rigidity (MMR) test positive for malignant hyperthermia susceptibility (MHS)?
50%
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In the management of masseter muscle rigidity (MMR) during emergent surgery, _______ is not recommended.
In the management of masseter muscle rigidity (MMR) during emergent surgery, prophylactic dantrolene is not recommended.
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What is the Gold Standard test for malignant hyperthermia susceptibility?
Caffeine-Halothane Contracture Test (CHCT)
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What are the sensitivity and specificity of the Caffeine-Halothane Contracture Test (CHCT)?
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Which of these is a known disadvantage of genetic testing for malignant hyperthermia susceptibility?
It is always less accurate than the CHCT.
A negative test does not rule out susceptibility.
It is more expensive than the CHCT.
It requires a muscle biopsy.
Which of these is a known disadvantage of genetic testing for malignant hyperthermia susceptibility?
It is always less accurate than the CHCT.
A negative test does not rule out susceptibility.
It is more expensive than the CHCT.
It requires a muscle biopsy.
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What is the initial dose and repetition protocol for Dantrolene in the management of an MH crisis?
Administer 2.5 mg/kg, repeating until symptoms are reversed up to 10 mg/kg.
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Which class of drugs is contraindicated in the management of MH-related dysrhythmias after the administration of Dantrolene?
Calcium Channel Blockers.
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What are the measures to prevent myoglobinuria-induced renal failure in the context of an MH crisis?
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The earliest clinical sign of Malignant Hyperthermia (MH) is _______.
The earliest clinical sign of Malignant Hyperthermia (MH) is increased ETCO2.
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What is the recommended cleaning procedure for an anesthesia machine before a case involving an MH-susceptible patient?
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Which medications may be used to treat dysrhythmias during an MH crisis?
Procainamide and lidocaine
Verapamil
Diltiazem
Amlodipine
Which medications may be used to treat dysrhythmias during an MH crisis?
Procainamide and lidocaine
Verapamil
Diltiazem
Amlodipine
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What is the primary risk associated with arm abduction exceeding 90 degrees in a surgical patient? 
Brachial plexus injury caused by the humeral head pushing into the axilla.
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During the _______ position, arm abduction must be limited to less than _______ to prevent brachial plexus injury.
During the supine position, arm abduction must be limited to less than 90 degrees to prevent brachial plexus injury.
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Which compensatory mechanism is attenuated by neuraxial anesthesia?
Sympathectomy
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How does neck flexion affect the ETT position?
It increases the risk of endobronchial intubation.
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What sex is specifically associated with an increased risk of ulnar neuropathy during surgery?
Male
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What is the effect of increased intrathoracic pressure on venous return (VR)?
Decreased venous return ($ o ext{VR}$)
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Which position is identified as the most common surgical position?
Prone
Lithotomy
Lateral decubitus
Supine
Which position is identified as the most common surgical position?
Prone
Lithotomy
Lateral decubitus
Supine
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What is the recommended intervention to mitigate back pain caused by the loss of normal lumbar lordotic curvature in the supine position?
Use a pillow under the knees.
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What is the primary cardiovascular effect of the Trendelenburg position?
Increased venous return and central venous pressure, leading to increased cardiac output.
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What happens to functional residual capacity (FRC) in the Trendelenburg position?
FRC decreases due to abdominal contents being displaced toward the diaphragm.
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What are the common potential complications associated with the Trendelenburg position?
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How does the Reverse Trendelenburg position affect cardiovascular parameters?
It decreases venous return, preload, cardiac output, and arterial blood pressure.
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The Reverse Trendelenburg position improves exposure for _______ and typically causes a _______ in cerebral perfusion.
The Reverse Trendelenburg position improves exposure for abdominal procedures and typically causes a decrease in cerebral perfusion.
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What is the effect of the lithotomy position on pulmonary function?
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What characterizes the 'Standard' lithotomy position?
Hips flexed at 90 degrees, knees bent with lower legs parallel to floor
Hips flexed at 30-45 degrees
Hips flexed at 90 degrees or more with greater knee extension
Hips flexed at 180 degrees
What characterizes the 'Standard' lithotomy position?
Hips flexed at 90 degrees, knees bent with lower legs parallel to floor
Hips flexed at 30-45 degrees
Hips flexed at 90 degrees or more with greater knee extension
Hips flexed at 180 degrees
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What is the effect of obesity on the pulmonary complications of the lithotomy position?
Obesity and Trendelenburg exacerbate these effects.
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Which nerve is the most commonly injured in the lithotomy position?
Common peroneal nerve
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Where should an axillary roll be placed in a patient in the lateral decubitus position?
Just caudal to the axilla, not in the axilla itself.
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What is the primary purpose of placing an axillary roll in the lateral decubitus position?
To prevent compression injury to the dependent brachial plexus and dependent axillary vascular structures.
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In the lateral decubitus position, which lung is favored by perfusion?
The dependent lung.
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In the lateral decubitus position, which lung is favored by ventilation in an anesthetized patient?
The non-dependent lung.
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Induction of anesthesia causes _______ FRC.
Induction of anesthesia causes decreased FRC.
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Lateral decubitus position complications include: - _______ - _______ - _______ - _______
Lateral decubitus position complications include: - impaired venous return - brachial plexus injury - pressure injuries - neck pain
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Which nerve injury can be caused by the shoulder rolling forward onto the dependent arm in the lateral decubitus position?
Femoral nerve
Obturator nerve
Suprascapular nerve
Common peroneal nerve
Which nerve injury can be caused by the shoulder rolling forward onto the dependent arm in the lateral decubitus position?
Femoral nerve
Obturator nerve
Suprascapular nerve
Common peroneal nerve
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What happens to venous return when the inferior vena cava is compressed in the prone position?
It becomes impaired.
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What effect does the prone position have on pulmonary compliance in obese patients?
It is improved, particularly when the abdomen is hanging freely.
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List three potential ocular complications of the prone position.
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When the head is rotated to the side for more than _______ in the prone position, there is a risk of _______.
When the head is rotated to the side for more than 3 hours in the prone position, there is a risk of cervical neuropathy.
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When a patient is in the sitting position, where should arterial blood pressure be measured?
At the level of the tragus.
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What happens to lung volumes and functional residual capacity (FRC) in the sitting position?
They increase.
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What is a potential risk of excessive neck flexion in the sitting position?
Edema of the face, tongue, and neck due to impaired venous drainage.
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What serious complication can occur in the sitting position due to stretching of the spinal cord?
Mid-cervical tetraplegia.
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Which of the following is an effect of the sitting position on cerebral blood flow?
No change
Increased
Decreased
Unpredictable
Which of the following is an effect of the sitting position on cerebral blood flow?
No change
Increased
Decreased
Unpredictable
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What is the consequence of stretching a nerve to 5% greater than its normal resting length?
It leads to ischemia due to the kinking of the arterioles and venules.
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Which peripheral nerve is the most frequently injured?
Ulnar nerve
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What forearm position helps avoid external compression of the ulnar nerve in the cubital tunnel?
Forearm supination
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What motor manifestation is characteristic of an ulnar nerve injury?
Loss of abduction, extension, or opposition of 4th and 5th fingers (claw hand).
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Radial nerve injury results in loss of dorsiflexion, a condition known as _______.
Radial nerve injury results in loss of dorsiflexion, a condition known as wrist drop.
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What clinical deformity is associated with a median nerve injury when a patient attempts to make a fist?
Hand of benediction or ape hand.
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According to the mnemonic 'DR CUMA', which nerve injury is associated with 'Claw Hand'?
Radial nerve
Femoral nerve
Ulnar nerve
Median nerve
According to the mnemonic 'DR CUMA', which nerve injury is associated with 'Claw Hand'?
Radial nerve
Femoral nerve
Ulnar nerve
Median nerve
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What are two clinical manifestations of an Ulnar nerve injury?
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What physical actions increase the risk of brachial plexus stretching injuries?
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Common peroneal injury is the _______ nerve in the lower extremity.
Common peroneal injury is the most frequently damaged nerve in the lower extremity.
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What is a common mechanism for peroneal nerve compression damage?
When the lateral aspect of the leg leans against a stirrup bar or candy canes, typically in the lithotomy position.
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What is the primary manifestation of an obturator nerve injury?
Inability to ADDUCT the leg.
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What is the cause of pudendal nerve injury during surgery?
Pressure from the perineal post of an orthopedic fracture table.
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What site is most susceptible to external pressure for a saphenous nerve injury?
The medial aspect of the leg.
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Which of the following is a manifestation of radial nerve injury?
Foot drop
Claw Hand
Inability to flex forearm
Wrist drop
Which of the following is a manifestation of radial nerve injury?
Foot drop
Claw Hand
Inability to flex forearm
Wrist drop
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What preventative measures should be taken to avoid venous air embolism during surgery?
Maintain adequate venous pressure and ligate 'open' veins.
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Which surgical positions are associated with the risk of alopecia?
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How can corneal abrasion be prevented during surgery?
Taping or lubricating the eye.
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What is the recommended prevention for brachial plexus nerve palsy during surgery?
Avoid stretching or direct compression at the neck, shoulder, or axilla.
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What surgical positions increase the risk of common peroneal nerve palsy?
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What prevention strategy is recommended for radial nerve palsy during surgery?
Avoid compression of the lateral humerus.
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What prevention strategy is recommended for ulnar nerve palsy during surgery?
Avoid sustained pressure on the ulnar groove.
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What is the recommended prevention for retinal ischemia during surgery?
Avoid pressure on the globe.
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What is the recommended prevention for skin necrosis during surgery?
Avoid sustained pressure over bony prominences.
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What is the primary definition of the AANA Code of Ethics?
It outlines expected behaviors for individuals who are part of the CRNA profession.
In the context of clinical practice, what are Standards of Care?
A set of rules or minimum requirements for clinical practice that ensures high quality patient care.
How are Standards of Care determined?
By individual hospital policies
By patient preference
By government decree only
By consensus and approval of recognized authoritative body
When can Standards of Care be modified?
Only under unusual circumstances, such as extreme emergencies or unavailability of equipment.
What is the fundamental difference between Standards of Care and Practice Guidelines?

AANA Standard 1 focuses on Patient Rights, emphasizing the respect for the patient's autonomy, dignity, and privacy.
AANA Standard 2 pertains to Pre-anesthesia Patient Assessment and Evaluation, which involves documenting the patient's general health, allergies, medication history, pre existing conditions, anesthesia history, and relevant diagnostic tests.
What documentation is required under Standard 4 regarding informed consent?
Obtain and document or verify that the patient or legal representative has given informed consent for planned anesthesia care or related services.
What is the frequency for documenting blood pressure, heart rate, and respiration during all anesthetics?
At least every five minutes.
According to Standard 6, how should anesthesia equipment be managed prior to each use?
Verify the function of anesthesia equipment prior to each anesthetic.
For patient ventilation, confirm intubation of the trachea or placement of airway devices by auscultation, chest excursion, and confirmation of expired carbon dioxide.
What safety measures should be taken regarding physiological monitoring device alarms?
Ensure variable pitch and threshold alarms are turned on and audible.
What is the primary responsibility of a CRNA when transitioning patient care to another professional?
Evaluate the patient's status and determine when it is appropriate to transfer responsibility, while communicating essential information for continuity of care.
What is the main goal of operating anesthesia equipment as described in Standard 6?
To maximize anesthesia output
To minimize the risk of fire, explosion, electrical shock, and equipment malfunction
To expedite patient recovery time
To reduce equipment maintenance costs
What is the ethical principle of Beneficence?
The obligation to do good.
Define negligence in the context of professional practice.
Medical malpractice is a form of professional negligence. 
What are the four required elements of proof for a plaintiff in a negligence case?
The Res ipsa loquitur doctrine translates to the thing speaks for itself, where the burden of proof of causation shifts from the plaintiff to the defendant.
When should a patient be informed of a medical risk?
Only when the risk is low and severity is great
Only when the severity is minor
Only when the patient specifically asks for details
When the risk is statistically high
What are the two types of Advanced Directives?
What is the function of a Medical Durable Power of Attorney?
It designates another person to make health care decisions for a patient if they become incompetent or unable to make such decisions themselves.
What is the classification for a Level 5 surgical urgency?
Within 24 hours.
What is an elective surgical procedure?
A procedure planned and scheduled in advance with no urgency.
What does a patient's physical and history assessment allow for during anesthesia planning?
Which herbal supplement use is noted as often overlooked?
Herbal supplements, which are used by up to 30% of the US population.
What are three examples of patient-related anesthetic history complications?
What condition might explain a prolonged duration of muscle relaxant effect in a patient?
Pseudocholinesterase deficiency.
For NPO status, it is important to document the last solid food, content and time and the last liquid intake.
When assessing airway requirements, what does the airway assessment allow for?
Planning for masking, intubation, or alternate airway modalities
Determining the patient's ASA physical status
Calculating the required dosage of muscle relaxants
Scheduling the procedure urgency level
What is the minimum fasting period required before surgery for clear liquids, such as water, black coffee, or pulp-free fruit juice?
2 hours
How long should a patient fast before surgery after consuming breast milk?
4 hours
What is the required minimum fasting period for nonhuman milk, such as infant formula?
6 hours
What is the required minimum fasting period for a light meal containing toast and clear liquids?
6 hours
What is the minimum fasting period for a regular or heavy meal, including fried or fatty food?
8 hours
In the ASA Physical Status Classification system, what does the addition of an 'E' denote?
Emergency surgery
According to the ASA Physical Status Classification, how is an 'ASA 1' patient described?
Healthy patients
Declared brain-dead patient
Severe disease process
Moribund patient
Which ASA classification level describes a patient who is moribund and not expected to survive 24 hours with or without an operation?
ASA 6
ASA 5
ASA 3
ASA 4
An emergency surgery is defined as existing when delay in treatment would lead to a significant increase in the threat to life or body part.
What is the clinical significance of an inability to achieve 4 METs?
It is associated with increased perioperative risk.
What is the formal definition of 1 MET?
It is defined as the energy used when resting or sitting still, equal to \(3.5 \text{ mL O}_2 / \text{kg} / \text{min}\).
Which six independent risk factors are included in the Revised Cardiac Risk Index (RCRI)?
The RCRI uses the following six independent predictors: - Ischemic heart disease - Congestive heart failure - Cerebrovascular disease - Diabetes mellitus treated with insulin - Serum creatinine \(> 2 \text{ mg/dL}\) - High-risk surgery (intraperitoneal, intrathoracic, or suprainguinal vascular)
What is the Revised Cardiac Risk Index (RCRI) primarily used for?
To assess metabolic equivalents
To measure long-term mortality
To assign perioperative cardiac risk
To diagnose coronary artery disease
Chronic hypertension affects autoregulation curves by causing a shift to the right and a narrowing of the plateau.
What are the common symptoms of unstable cardiac disease that require further evaluation?
What activities require an energy expenditure of 4 METs according to the estimation table?

What are the common symptoms of aortic stenosis (AS) or its disease progression?
What is the recommended interval for interrogating a patient's pacemaker?
Every 12 months
What is the recommended interval for interrogating a patient's ICD?
Every 6 months
For patients with coronary artery stents, the delay for elective surgery should be 30 days for bare metal stents (BMS) and 365 days for drug-eluting stents (DES).
What happens when a magnet is placed over an implanted cardioverter-defibrillator (ICD)?
It inhibits arrhythmia detection.
How many risk factors for CAD indicate an intermediate risk level for pre-operative testing?
0-1
2
3
4
What does a systolic murmur in the right second intercostal space indicate?
Aortic stenosis
According to AHA/ACC guidelines, preoperative echocardiography is required for moderate to severe valvular stenosis or regurgitation if no studies have been performed within 1 year or if there is worsening clinical status.
What are the components of the STOP-Bang screening tool for obstructive sleep apnea?
What is considered a high-risk score on the STOP-Bang screening tool?
4+
2+
0-3
5+
What happens to the body 24-48 hours after smoking cessation?
- Decrease in nicotine levels
- Decrease in CV (cardiovascular) effects
- Decrease in carbon monoxide levels
What improvements occur 6-8 weeks after smoking cessation?
- Improvement in ciliary function
- Decrease in mucus production
Long-term benefits of smoking cessation include an addition of 6 to 8 years life expectancy and a reduced risk of lung cancer and heart disease.
What are three common GI and hepatic conditions assessed in a preoperative history?
What conditions are commonly noted in a renal assessment?
What are three blood-related conditions relevant to a hematologic assessment?
What is the normal measurement for the interincisor gap (IIG) during a preoperative airway exam?
Normal = 3 finger breadths or 5 cm
What is the normal thyromental distance (TMD) measurement?
Normal = 3 finger breadths or 6.5 cm
For the airway exam, c-spine extension is necessary to align the axes and visualize the vocal cords.
During an airway exam, the presence of ridges from the patient's teeth on the tongue is a sign that the tongue does not have much room.
What does the upper lip bite test signify during an airway exam?
Difficult intubation
Macroglossia
Reduced neck extension
Good mobility
Why is macroglossia problematic during intubation?
The tongue has to be displaced, and the larger the tongue, the more difficult it is to gain control of it.
The preoperative physical exam includes assessing vital signs, height/weight/BMI, general appearance, and breath sounds.
What structures are visible in a Mallampati Class 1 airway? 
Full view of the soft palate, uvula, and tonsillar pillars.
Which Mallampati class is characterized by the soft palate and upper portion of the uvula being visible?
Class 2.
What is the visibility expectation for a Mallampati Class 3 airway?
Just the soft palate is visible; the uvula is not.
What structure is visible in a Mallampati Class 4 airway?
Only the hard palate.
Predictors of difficult intubation include an interincisor distance of less than 3 cm.
A patient with a 'thick neck' is a predictor of difficult intubation if the circumference is greater than 17 in in males or 16 in in females.
Which of the following is considered a predictor of difficult mask ventilation?
Long neck
Young age
Obesity
High range of motion of C-spine
Besides obesity and male gender, what is another anatomical predictor of difficult mask ventilation related to the face?
Beard.
According to the 2012 ASA Practice Advisory, how should pre-op tests be ordered for asymptomatic patients?
They should only be ordered after considering information obtained from the medical record, H&P, and the type or invasiveness of the planned procedure and anesthesia.
What are the clinical indications for ordering a preoperative CBC?
What factors should the decision to order T&S (Type and Screen) or T&C (Type and Crossmatch) be based on?
For preoperative blood conservation, strategies should be considered to minimize the use of allogeneic blood.
How long prior to the date of surgery (DOS) should NSAIDs be held?
2-7 days prior to DOS.
How long prior to the date of surgery (DOS) should Coumadin be held?
5 days prior to DOS.
Which of the following medications should be continued before surgery?
GLP-1 Agonists
Statins
Diuretics
NSAIDs
What is the recommended pre-operative hold time for St. John's Wort?
At least 5 days prior to the date of surgery.
What is the recommended pre-operative hold time for Enbrel?
2 weeks prior to surgery.
How should high-risk antiplatelet therapy be managed before surgery?
Hold clopidogrel and continue ASA.
What is the upper limit for glucose control in Type 1 diabetic patients undergoing surgery?
Less than 200 mg/dL
When should antibiotics be administered in relation to the incision?
Within 1 hour prior to incision
What is the recommended antibiotic strategy if a procedure is prolonged beyond two half-lives?
Redose the antibiotic
What dosage adjustment is required for morbidly obese patients receiving antibiotic prophylaxis?
Twice the dose of normal weight patients
Which antibiotics should be used for surgical prophylaxis in patients with a penicillin allergy?
Vancomycin or clindamycin
What criteria define Mendelson's syndrome?
Volume > 25 mL and pH < 2.5
What is the most significant ranked risk factor for pulmonary aspiration?
Obesity
Emergency surgery
GERD
Opioid use
Routine pharmacologic prophylaxis for aspiration is not recommended in otherwise healthy patients with no risk factors undergoing elective procedures.
What is the primary clinical benefit of administering Sodium Citrate prior to anesthesia?
It minimizes the risk of lung injury by increasing the pH of gastric fluid.
Why should Metoclopramide be avoided in patients with a suspected bowel obstruction?
Because it increases gastric motility, which could precipitate complications like bowel perforation.
Which type of antacid is contraindicated for use due to the risk of serious pulmonary sequelae if aspirated?
Nonparticulate antacids (e.g., Sodium Citrate)
Histamine-2 receptor antagonists
Proton pump inhibitors
Particulate antacids (e.g., Tums, Rolaids)
How do Histamine-2 receptor antagonists affect gastric secretions?
They decrease gastric volume and acidity by blocking the ability of histamine to induce secretion of gastric fluid with a high \(H^+\) concentration.
Among H2 receptor antagonists, Famotidine has the longest duration of action, typically lasting 10-12 hours.
What is the primary mechanism of action for Proton Pump Inhibitors (PPIs)?
They suppress gastric acid secretion by binding to the proton pump of the parietal cells.
List three primary goals of administering pre-operative medication.

Extreme caution should be used with pre-op sedation in patients with intracranial pathology, severe pulmonary disease, or hypovolemia.
What is the primary action of Dexmedetomidine as an alpha-2 agonist?
It produces sedation and attenuates the sympathetic nervous system response to stimulation.
What is a characteristic side effect of opioid administration regarding gastrointestinal function?
Delayed gastric emptying.
Which anticholinergic medication listed is known to be more potent than Atropine for antisialagogue effects?
Glycopyrrolate.
Which drug is categorized as a Quaternary Amine anticholinergic that does not easily cross the blood-brain barrier?
Glycopyrrolate
Atropine
Midazolam
Scopolamine
According to the table comparing anticholinergics, which agent has the strongest sedative and amnesic effects?
Scopolamine
The most common benzodiazepine used in anesthetic practice is Midazolam, which is valued for its rapid onset and recovery.
Why is the routine use of anticholinergics considered uncommon?
Due to side effects such as CNS toxicity, tachycardia, pupil dilation, relaxation of the lower esophageal sphincter, inhibition of sweating, and thickened secretions.
What are the five main risk factors for PONV in adults? 
Which of the following is a recommended strategy to mitigate PONV?
Routine use of nitrous oxide
Avoidance of hydration
Increased use of volatile anesthetics
Use of regional anesthesia
For patients with 1-2 risk factors for PONV, give 2 agents; for patients with > 2 risk factors, give 3-4 agents.
What is the recommended newer stress-dose steroid treatment for the first day of surgery?
100 mg hydrocortisone IV followed by 50 mg IV q8 hours.
Potential adverse effects of stress-dose steroid treatment include: - Hypertension - Hyperglycemia - Increased risk of infection - Delayed wound healing - Electrolyte disturbance/Fluid retention
What is the typical prophylactic combination used against allergic reactions?
H1 (Benadryl) + H2 (Zantac/Pepcid) + Steroid (hydrocortisone)
Pretreatment with a combination of H1 and H2 antagonists is more effective than H1 antagonists alone.
What are the five major goals of general anesthesia?
During which stage of Guedel's anesthesia is 'Excitement' observed?
Stage 3
Stage 2
Stage 4
Stage 1
What are the pupil characteristics in Guedel's Stage 4 anesthesia?
Dilated and unreactive
In Guedel's classification, Stage 1 is also known as the Induction Period or Analgesia.
What is the primary characteristic of Guedel's Stage 4 anesthesia?
Anesthetic Crisis (breathing stops to death)
What occurs during Plane 4 of Guedel's Stage 3 (Surgical Anesthesia)?
Complete intercostal paralysis to diaphragmatic paralysis, apnea, and loss of respiratory effort.
In Guedel's Stage 3, Plane 3, what happens to the light reflex?
It is abolished.
What are the physiological signs associated with Guedel's Stage 2 (Excitement)?
- Irregular respiration
- Breath holding
- Pupillary dilation
What mnemonic is used for pre-induction anesthesia tasks?
MS. MAIDS
What does each letter in the 'MS. MAIDS' mnemonic stand for in the context of pre-induction anesthesia tasks?
The components of the MS. MAIDS mnemonic are: - Machine - Suction - Monitors - Airway - IV access - Drugs - Special
What is the primary goal of administering pre-induction medications?
Blunt hemodynamic (HD) response to direct laryngoscopy (DL).
What are two ways to achieve preoxygenation for anesthesia induction?
How is loss of consciousness (LOC) assessed during pre-induction?
By checking the lash reflex, then taping the eyes.
List four methods to verify endotracheal tube (ETT) placement.
What is a standard component of pre-induction documentation?
Discharge summary
Informed consent obtained
Post-operative pain scale
Patient insurance verification
What is the primary goal of Rapid Sequence Induction (RSI)?
To minimize aspiration risk.
What is the clinical endpoint for preoxygenation in RSI?
\(ETO_2 > 90\%\)
When should cricoid pressure be applied and released during RSI?
The Cormack-Lehane Grade 1 view indicates a complete or nearly complete view of the glottic opening.
Which of the following is a contraindication to the use of succinylcholine (SCh) for RSI?
Full stomach
Pregnancy
Malignant hyperthermia (MH) susceptibility
GERD
Based on the Cormack-Lehane scale, what is visible in a Grade 3 view?
Epiglottis only.
What is the definition of fasciculations seen with succinylcholine induction?
SCh-induced involuntary muscle contractions.
Using the provided Cormack-Lehane grading scale illustration, which grade displays only the soft palate?
Grade 4
What are some clinical indications for using Total Intravenous Anesthesia (TIVA)?
What categories of drugs are commonly used in Balanced Anesthesia?
What are the minimum recording intervals for vital signs (BP, HR, RR) during maintenance of anesthesia?
Every 5 minutes
What specific patient safety documentation must occur every 30 minutes regarding body position?
Documentation of the assessment of position changes.
Intraoperative documentation of critical events (such as cardiac arrest, anaphylactic reaction, difficult airway, or EKG changes) usually requires a separate note in the patient's chart.
Which of the following monitoring parameters is required to be documented at a minimum interval of every 15 minutes?
BP, HR, RR
Rate, Vt, PIP, PEEP
O2, N2O, or air
SaO2, FiO2, ETCO2
Regarding the surgical time-out, what items are included in the verification checklist?
- Patient identified
- Procedure confirmed
- Consent / H&P
- Site marking visible
- Diagnostics / images available
- Allergies verified
- Antibiotics verified
- Beta blocker verified
- Implants verified
- Blood verified
- DVT prophylaxis verified
What clinical signs are associated with 'Light Anesthesia' when Neuromuscular Blocking Drugs (NMBD) are present?
What are the cardiovascular effects of excessive 'deep anesthesia'?
Which of the following is considered a patient group less suited for deep extubation?
Obese patients
Patients with no history of aspiration
Patients with low BMI
Patients with high tidal volume
The requirements for awake extubation include: - Breathing frequency < 30 breaths/min - Maximum inspiratory pressure < -20 cm \(H_2O\) - Vital capacity > 15 mL/kg - Tidal volume > 6 mL/kg
According to the comparative table, what is a primary 'Con' of awake extubation?
Increased coughing risk. 
What does a deep extubation attempt to avoid?
Coughing and bucking.
For deep extubation, the ETT is removed prior to wake up and prior to return of upper airway reflexes.
List the three items that must be verbally confirmed by the surgeon, anesthesia professional, and nurse before skin incision.
What is the Aldrete score required to meet discharge criteria?
9-10
According to the Aldrete Scoring system, what oxygen saturation value indicates a score of 2?
\(SpO_2 > 92\%\) on RA
What blood pressure criteria is needed for a score of 2 in the circulation category of the Aldrete score?
BP within \(20\text{ mmHg}\) of preanesthetic value (min SBP = \(90\text{ mmHg}\))
For the consciousness category of the Aldrete score, a patient who is fully awake receives a score of 2, while a patient who is arousable to voice receives a score of 1.
What is the score for a patient who is apneic in the respiration category of the Aldrete scoring system?
0
3
2
1
When is the anesthesia end time documented?
When care is transferred to PACU/ICU
In the context of follow-up post-op notes, how often should inpatients be seen after discharge from PACU?
At least once within 48 hours
What elements should be included in a PACU handoff?
What is the leading cause of anesthesia-related malpractice claims?
Death (30%)
Name three causes of severe hypoxemia in the context of anesthesia. 
What are three common causes of reduced cardiac output leading to cerebral ischemia under anesthesia? 
The psychological consequences of anesthesia awareness can include sleep disturbances, work & social impairment, and PTSD.
List four risk factors associated with anesthesia awareness.
What are three pharmacological or monitoring strategies used to mitigate the risk of anesthesia awareness?
What is the most common reported eye injury related to anesthesia?
Corneal abrasion.
What are three causes of corneal abrasion during anesthesia?
Which surgical positions or procedures are risk factors for ischemic optic neuropathy?
What are the causes of central retinal artery occlusion?
Mendelson's syndrome is a type of chemical pneumonitis caused by the aspiration of gastric contents with a pH of less than 2.5 and a volume of 0.3 ml/kg or greater.
What are the prevention strategies for Mendelson's syndrome?
What is the primary genetic defect associated with malignant hyperthermia?
A defect in the genes coding for ryanodine receptors (RYR1).
What classes of agents are known to trigger malignant hyperthermia?
What are the earliest clinical signs of malignant hyperthermia?
Malignant hyperthermia is inherited in an autosomal dominant pattern, meaning that one defective gene is needed for the disease to manifest.
What is a major consequence of sustained hypermetabolism in malignant hyperthermia related to muscle cell breakdown?
Decrease in core temperature
Decreased \(ETCO_2\) levels
Release of myoglobin, \(K^+\), and CK
Improved muscle oxygenation
What physiological event occurs when triggering agents react with RYR1 receptors, initiating a hypermetabolic state?
Uncontrolled \(Ca^{2+}\) release from the sarcoplasmic reticulum into the myoplasm.
What condition occurs if the body temperature reaches or exceeds \(41^{\circ} C\) during a malignant hyperthermia crisis?
Death usually due to DIC (disseminated intravascular coagulation).
What are two specific musculoskeletal complications resulting from rhabdomyolysis in malignant hyperthermia?
What is the mechanism of action of dantrolene?
It is a specific RYR1 receptor antagonist that prevents \(Ca^{2+}\) release from the SR and RYR1/DHP receptor coupling.
What is the initial recommended dose of dantrolene for the treatment of malignant hyperthermia?
\(2.5\text{ mg/kg}\)
Which of the following is true regarding the new formulation of dantrolene (Ryanodex) compared to the original (Dantrium)?
It is 150 times more concentrated.
It takes 860 seconds to mix.
It requires 60 ml of sterile water.
It is less expensive than the original formulation.
Delays in treatment are associated with high rates of complications and death in MH-related cases.
What are the three main categories of causes for Neuroleptic Malignant Syndrome?
How do NMS and MH compare regarding inheritance and onset time?
NMS is not inherited and takes 24-72 hours or several weeks to develop. MH is inherited and has early onset within minutes.
Which drug is used as a dopaminergic agonist for the treatment of Neuroleptic Malignant Syndrome?
Bromocriptine
Which of the following is a symptom of Neuroleptic Malignant Syndrome?
Bradycardia
Muscle rigidity
Hypothermia
Increased dopamine activity
What three myopathic disorders are associated with susceptibility to malignant hyperthermia?
What percentage of patients with masseter muscle rigidity (MMR) test positive for malignant hyperthermia susceptibility (MHS)?
50%
In the management of masseter muscle rigidity (MMR) during emergent surgery, prophylactic dantrolene is not recommended.
What is the Gold Standard test for malignant hyperthermia susceptibility?
Caffeine-Halothane Contracture Test (CHCT)
What are the sensitivity and specificity of the Caffeine-Halothane Contracture Test (CHCT)?
Which of these is a known disadvantage of genetic testing for malignant hyperthermia susceptibility?
It is always less accurate than the CHCT.
A negative test does not rule out susceptibility.
It is more expensive than the CHCT.
It requires a muscle biopsy.
What is the initial dose and repetition protocol for Dantrolene in the management of an MH crisis?
Administer 2.5 mg/kg, repeating until symptoms are reversed up to 10 mg/kg.
Which class of drugs is contraindicated in the management of MH-related dysrhythmias after the administration of Dantrolene?
Calcium Channel Blockers.
What are the measures to prevent myoglobinuria-induced renal failure in the context of an MH crisis?
The earliest clinical sign of Malignant Hyperthermia (MH) is increased ETCO2.
What is the recommended cleaning procedure for an anesthesia machine before a case involving an MH-susceptible patient?
Which medications may be used to treat dysrhythmias during an MH crisis?
Procainamide and lidocaine
Verapamil
Diltiazem
Amlodipine
What is the primary risk associated with arm abduction exceeding 90 degrees in a surgical patient? 
Brachial plexus injury caused by the humeral head pushing into the axilla.
During the supine position, arm abduction must be limited to less than 90 degrees to prevent brachial plexus injury.
Which compensatory mechanism is attenuated by neuraxial anesthesia?
Sympathectomy
How does neck flexion affect the ETT position?
It increases the risk of endobronchial intubation.
What sex is specifically associated with an increased risk of ulnar neuropathy during surgery?
Male
What is the effect of increased intrathoracic pressure on venous return (VR)?
Decreased venous return ($ o ext{VR}$)
Which position is identified as the most common surgical position?
Prone
Lithotomy
Lateral decubitus
Supine
What is the recommended intervention to mitigate back pain caused by the loss of normal lumbar lordotic curvature in the supine position?
Use a pillow under the knees.
What is the primary cardiovascular effect of the Trendelenburg position?
Increased venous return and central venous pressure, leading to increased cardiac output.
What happens to functional residual capacity (FRC) in the Trendelenburg position?
FRC decreases due to abdominal contents being displaced toward the diaphragm.
What are the common potential complications associated with the Trendelenburg position?
How does the Reverse Trendelenburg position affect cardiovascular parameters?
It decreases venous return, preload, cardiac output, and arterial blood pressure.
The Reverse Trendelenburg position improves exposure for abdominal procedures and typically causes a decrease in cerebral perfusion.
What is the effect of the lithotomy position on pulmonary function?
What characterizes the 'Standard' lithotomy position?
Hips flexed at 90 degrees, knees bent with lower legs parallel to floor
Hips flexed at 30-45 degrees
Hips flexed at 90 degrees or more with greater knee extension
Hips flexed at 180 degrees
What is the effect of obesity on the pulmonary complications of the lithotomy position?
Obesity and Trendelenburg exacerbate these effects.
Which nerve is the most commonly injured in the lithotomy position?
Common peroneal nerve
Where should an axillary roll be placed in a patient in the lateral decubitus position?
Just caudal to the axilla, not in the axilla itself.
What is the primary purpose of placing an axillary roll in the lateral decubitus position?
To prevent compression injury to the dependent brachial plexus and dependent axillary vascular structures.
In the lateral decubitus position, which lung is favored by perfusion?
The dependent lung.
In the lateral decubitus position, which lung is favored by ventilation in an anesthetized patient?
The non-dependent lung.
Induction of anesthesia causes decreased FRC.
Lateral decubitus position complications include: - impaired venous return - brachial plexus injury - pressure injuries - neck pain
Which nerve injury can be caused by the shoulder rolling forward onto the dependent arm in the lateral decubitus position?
Femoral nerve
Obturator nerve
Suprascapular nerve
Common peroneal nerve
What happens to venous return when the inferior vena cava is compressed in the prone position?
It becomes impaired.
What effect does the prone position have on pulmonary compliance in obese patients?
It is improved, particularly when the abdomen is hanging freely.
List three potential ocular complications of the prone position.
When the head is rotated to the side for more than 3 hours in the prone position, there is a risk of cervical neuropathy.
When a patient is in the sitting position, where should arterial blood pressure be measured?
At the level of the tragus.
What happens to lung volumes and functional residual capacity (FRC) in the sitting position?
They increase.
What is a potential risk of excessive neck flexion in the sitting position?
Edema of the face, tongue, and neck due to impaired venous drainage.
What serious complication can occur in the sitting position due to stretching of the spinal cord?
Mid-cervical tetraplegia.
Which of the following is an effect of the sitting position on cerebral blood flow?
No change
Increased
Decreased
Unpredictable
What is the consequence of stretching a nerve to 5% greater than its normal resting length?
It leads to ischemia due to the kinking of the arterioles and venules.
Which peripheral nerve is the most frequently injured?
Ulnar nerve
What forearm position helps avoid external compression of the ulnar nerve in the cubital tunnel?
Forearm supination
What motor manifestation is characteristic of an ulnar nerve injury?
Loss of abduction, extension, or opposition of 4th and 5th fingers (claw hand).
Radial nerve injury results in loss of dorsiflexion, a condition known as wrist drop.
What clinical deformity is associated with a median nerve injury when a patient attempts to make a fist?
Hand of benediction or ape hand.
According to the mnemonic 'DR CUMA', which nerve injury is associated with 'Claw Hand'?
Radial nerve
Femoral nerve
Ulnar nerve
Median nerve
What are two clinical manifestations of an Ulnar nerve injury?
What physical actions increase the risk of brachial plexus stretching injuries?
Common peroneal injury is the most frequently damaged nerve in the lower extremity.
What is a common mechanism for peroneal nerve compression damage?
When the lateral aspect of the leg leans against a stirrup bar or candy canes, typically in the lithotomy position.
What is the primary manifestation of an obturator nerve injury?
Inability to ADDUCT the leg.
What is the cause of pudendal nerve injury during surgery?
Pressure from the perineal post of an orthopedic fracture table.
What site is most susceptible to external pressure for a saphenous nerve injury?
The medial aspect of the leg.
Which of the following is a manifestation of radial nerve injury?
Foot drop
Claw Hand
Inability to flex forearm
Wrist drop
What preventative measures should be taken to avoid venous air embolism during surgery?
Maintain adequate venous pressure and ligate 'open' veins.
Which surgical positions are associated with the risk of alopecia?
How can corneal abrasion be prevented during surgery?
Taping or lubricating the eye.
What is the recommended prevention for brachial plexus nerve palsy during surgery?
Avoid stretching or direct compression at the neck, shoulder, or axilla.
What surgical positions increase the risk of common peroneal nerve palsy?
What prevention strategy is recommended for radial nerve palsy during surgery?
Avoid compression of the lateral humerus.
What prevention strategy is recommended for ulnar nerve palsy during surgery?
Avoid sustained pressure on the ulnar groove.
What is the recommended prevention for retinal ischemia during surgery?
Avoid pressure on the globe.
What is the recommended prevention for skin necrosis during surgery?
Avoid sustained pressure over bony prominences.
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