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Why is it important to ensure lower extremity function with epidural anesthesia?
It facilitates early ambulation, supporting faster recovery.
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What is Mendelson syndrome associated with in terms of gastric pH and volume?
Gastric pH < 2.5 and volume > 25 mL or 0.4 mL/kg.
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Why is esophageal disease (e.g., varices) a relative contraindication?
Because it increases the risk of traumatic esophageal injury.
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What is the effect of reduced left ventricular (LV) preload on stroke volume?
Reduced LV preload leads to a decrease in stroke volume.
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What causes restricted RV filling during positive pressure inspiration?
Pulmonary vein compression and increased pleural pressure.
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How does positive pressure inspiration affect right ventricular (RV) filling?
It restricts right ventricular (RV) filling due to pulmonary vein compression and increased pleural pressure.
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How does positive pressure inspiration affect left ventricular (LV) filling?
It enhances left ventricular (LV) filling.
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What traditional indicators were once used to assess fluid balance, and what has replaced them?
Traditional indicators included heart rate, MAP (mean arterial pressure), and CVP (central venous pressure). These have been replaced by dynamic measures of fluid responsiveness.
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How does surgery affect fluid retention?
ADH (antidiuretic hormone) is released during surgery, causing fluid retention for several days.
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Treatment for non-gap acidosis
• Sodium bicarbonate is more commonly used
• Most causes involve bicarbonate loss
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What is the treatment for Uremia/drug-induced metabolic acidosis?
Dialysis
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What is the caution of NaHCO3 in intracellular acidosis?
Caution: NaHCO₃ may worsen intracellular acidosis if ventilation
or perfusion is inadequate
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Relationship Between CO₂ Production and Ventilation (calculation)
PaCO₂ = CO₂ Production ÷ Alveolar Ventilation
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What happens to the chloride shift in the lungs?
The chloride shift reverses—Cl⁻ exits erythrocytes as CO₂ is exhaled and HCO₃⁻ re-enters the cell.
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What is the chloride (Hamburger) shift?
The chloride shift refers to Cl⁻ entering erythrocytes to maintain electrical neutrality as bicarbonate (HCO₃⁻) exits the cell. In the lungs, the shift reverses as CO₂ is exhaled.
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How are hydrogen ions (H⁺) and bicarbonate ions (HCO₃⁻) buffered during gas exchange in the blood?
H⁺ is buffered by hemoglobin; HCO₃⁻ is transported into plasma as a buffer.
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What is the normal total plasma magnesium level?
1.7–2.4 mg/dL (1.5–2.1 mEq/L)
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What percentage of total body magnesium is found in extracellular fluid?
1% (0.3% in plasma)
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Where is the majority of magnesium stored in the body?
Intracellularly (muscle and bone)
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What does serum magnesium not reflect?
Total body magnesium stores
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How does magnesium affect calcium's effects?
Counteracts calcium’s effects
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What is magnesium essential for in the body?
DNA synthesis and enzymatic reactions
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Why is magnesium critical for cardiac function?
It supports normal cardiac function
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Where is most magnesium reabsorbed in the body?
In the renal tubules
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What is the IV dosage for managing pre-eclampsia with magnesium?
4 g IV over 10–15 minutes, then 1 g/hr for 24 hours
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What risk increases with magnesium use beyond 48 hours in pre-eclampsia?
Neonatal respiratory depression, hypotension, and lethargy (mag crosses placenta)
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How does magnesium act as an opioid-sparing adjunct?
Through NMDA receptor antagonism
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What condition is magnesium used to treat related to bronchospasm?
Acute bronchospasm
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What cardiac rhythm disturbances can magnesium help manage?
Symptomatic PVCs and Torsades de pointes
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What can hypermagnesemia enhance?
Neuromuscular blockade effects (succinylcholine and nondepolarizing agents)
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What should be considered in preeclamptic patients receiving magnesium?
Caution with emergent C-sections
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What is the normal blood pH range?
7.35 – 7.45
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What is acidosis defined as?
pH < 7.35
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What is alkalosis defined as?
pH > 7.45
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What does the Henderson-Hasselbalch equation describe?
pH as a function of the ratio of [A⁻] to [HA]
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What does pKa represent in the Henderson-Hasselbalch equation?
Negative log of the acid dissociation constant
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What does [A⁻] represent in the equation?
Concentration of the conjugate base (e.g., bicarbonate HCO₃⁻)
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What does [HA] represent in the equation?
Concentration of the weak acid (e.g., carbonic acid H₂CO₃)
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What does PaCO₂ represent in the Henderson-Hasselbalch equation?
Partial pressure of CO₂ in arterial blood
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What is the normal bicarbonate concentration ([HCO₃⁻])?
24 mEq/L
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What is the normal PaCO₂ level?
40 mmHg
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What is the pH of blood when substituting normal values into the Henderson-Hasselbalch equation?
7.4
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What does the 0.03 in the Henderson-Hasselbalch equation refer to?
Solubility coefficient of CO₂ in plasma
Specifically: It represents how much dissolved CO₂ is present in blood plasma per mmHg of PCO₂.
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What is the major by-product of aerobic metabolism?
CO₂, diffusing into capillary blood.
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How is most CO₂ buffered in the blood?
A small amount dissolves in plasma.
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What percentage of CO₂ is transported as bicarbonate?
70%
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What percentage of CO₂ is bound to hemoglobin?
23%
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What percentage of CO₂ is dissolved in plasma?
7%
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How does venous blood PvCO₂ compare to arterial blood PaCO₂?
PvCO₂ is ~5 mmHg higher than PaCO₂.
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What is the arterial pH?
7.40
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What is the venous pH?
7.36
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What is the Bohr effect?
Acidic environments enhance O₂ offloading from hemoglobin.
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What is the Haldane effect?
Acidic environments increase CO₂ binding to hemoglobin.
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How is CO₂ removed from the body?
Via alveolar ventilation.
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What happens to pulmonary blood pH as CO₂ is eliminated?
It rises. This facilitates CO₂ offloading from hemoglobin.
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What is the CO₂ transport reaction?
H₂O + CO₂ ⇌ H₂CO₃ ⇌ H⁺ + HCO₃⁻
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What enzyme is essential for the CO₂ transport reaction?
Carbonic anhydrase.
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Where is carbonic anhydrase found?
Inside RBCs, not in plasma.
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What does carbonic anhydrase catalyze?
Formation of carbonic acid from H₂O and CO₂.
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What does carbonic acid quickly dissociate into?
H⁺ and HCO₃⁻.
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What maintains electrical neutrality in erythrocytes?
Cl⁻ enters erythrocytes (Chloride shift).
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What happens to erythrocytes in venous circulation due to Cl⁻?
They swell, increasing venous hematocrit by ~3% higher than arterial hematocrit (swelling process reverses in the lungs).
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What is the normal range for PaCO₂?
35 – 45 mmHg
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What indicates a respiratory disorder?
pH and PaCO₂ move in opposite directions.
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What indicates respiratory acidosis?
↓ pH, ↑ CO₂
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What indicates respiratory alkalosis?
↑ pH, ↓ CO₂
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What is the normal range for HCO₃⁻?
22 – 26 mEq/L
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What indicates a metabolic disorder?
pH and HCO₃⁻ move in the same direction.
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What indicates metabolic acidosis?
↓ pH, ↓ HCO₃⁻
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What indicates metabolic alkalosis?
↑ pH, ↑ HCO₃⁻
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What is the normal range for the anion gap?
8–12 mEq/L
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What does the ROME mnemonic stand for?
Respiratory Opposite, Metabolic Equal.
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What is full compensation?
pH is fully restored to normal.
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What is partial compensation?
pH improves but remains outside the normal range.
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What is respiratory compensation?
Rapid changes driven by ventilation. (respiratory compensation to the kidneys is slow)
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What is metabolic compensation?
Slow changes due to altered H⁺ excretion by kidneys. (metabolic changes driven by changes in ventilation is fast)
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What indicates a mixed disorder?
Suspect mixed if:
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What should you check if PaO₂ is normal?
Calculate the A-a gradient to assess for a shunt.
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What is the A-a gradient used for?
To assess for a shunt and its severity.
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What causes respiratory acidosis?
• Occurs when alveolar ventilation cannot keep up with CO₂ production.
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What is the treatment focus for respiratory acidosis?
Correcting the underlying cause.
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When is mechanical ventilation indicated for respiratory acidosis?
If pH < 7.20.
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What is hypercapnia?
PaCO₂ > 45 mmHg.
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What is hypocapnia?
PaCO₂ < 35 mmHg.
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How do kidneys compensate for respiratory acidosis?
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How long does full compensation for respiratory acidosis take?
Several days.
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What causes respiratory alkalosis?
Alveolar ventilation exceeds CO₂ production.
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What are the common causes of respiratory alkalosis?
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How do kidneys compensate for respiratory alkalosis?
Excrete bicarbonate (HCO₃⁻).
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What is the primary goal in treating respiratory alkalosis?
Identify and correct the underlying cause.
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What are the causes of metabolic acidosis?
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What is the Anion Gap formula?
Anion Gap = Na⁺ - (Cl⁻ + HCO₃⁻)
• Helps identify the underlying cause of metabolic acidosis
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What is the normal range for Anion Gap?
8–12 mEq/L.
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What is the difference between gap and non-gap acidosis?
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How does the body compensate for metabolic acidosis?
By increasing minute ventilation to eliminate CO₂.
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What is the Respiratory Compensation Rule?
PaCO₂ decreases by 1–1.5 mmHg for every 1 mEq/L drop in HCO₃⁻.
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When is sodium bicarbonate used in anion gap acidosis?
If pH < 7.2 and patient is hemodynamically unstable.
• Bicarbonate may help when acidosis impairs enzyme function
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What is the treatment for lactic acidosis?
IVF, oxygen, cardiopulmonary support.
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What is the treatment for DKA?
IVF, insulin.
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What causes metabolic alkalosis?
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How does the body compensate for metabolic alkalosis?
By retaining CO₂ through decreased ventilation.
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How does PaCO₂ change with each 1 mEq/L rise in HCO₃⁻?
Increases by 0.5–1 mmHg for every 1 mEq/L rise in HCO₃⁻
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What is the first step in treating metabolic alkalosis?
Address the underlying cause
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What is acetazolamide used for in metabolic alkalosis?
Promotes renal bicarbonate excretion (carbonic anhydrase inhibitor)
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What role does spironolactone play in metabolic alkalosis?
Acts as a mineralocorticoid antagonist
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What is the treatment for severe or refractory cases of metabolic alkalosis?
Dialysis
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What is the 4:2:1 Rule for fluid maintenance?
4 mL/kg/hr for first 10 kg of body weight, 2 mL/kg/hr for second 10 kg, 1 mL/kg/hr each kg thereafter 20 kg
for adults: body wt (kg) + 40 ml/hr
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How do you calculate the estimated fluid deficit?
Fasting hours × Hourly maintenance rate
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What is the fluid replacement for very minimal trauma?
1–2 mL/kg/hr
• e.g., Orofacial surgery
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What is the fluid replacement for minimal trauma?
2–4 mL/kg/hr
• e.g., Inguinal hernia repair
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What is the fluid replacement for moderate trauma?
4–6 mL/kg/hr
• e.g., Major nonabdominal surgery
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What is the fluid replacement for severe trauma?
6–8 mL/kg/hr
• e.g., Major abdominal surgery
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What is the crystalloid replacement ratio for blood loss?
3:1 (3 mL crystalloid per 1 mL blood lost)
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What is the colloid/blood replacement ratio for blood loss?
1:1 (1 mL per 1 mL blood lost)
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What is the maintenance IV fluid rate for a 17 kg patient?
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What is the maintenance IV fluid rate for an 8 kg patient?
4 mL/kg/hr for the first 10 kg = 40 mlAnswer = 32 mL/hr
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What is the maintenance IV fluid rate for a 120 kg patient?
Body weight (120 kg) + 40 mL
Answer = 160 mL/hr
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What misconception existed about preoperative fasting?
Thought to cause dehydration, but intravascular volume remains mostly unaffected
• Patients can now drink clear fluids up to 2 hours before surgery
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What is the issue with 'third space' fluid loss?
Minimal evidence supports its significance; may lead to excessive fluid administration
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What is the current practice for blood loss replacement?
Guide replacement by fluid responsiveness
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What was the historical approach to managing post-induction hypotension?
Managed with fluid, but often caused by vasodilation, better treated with vasopressors
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Why is urine output unreliable during surgery?
ADH limits urine output, making it unreliable during surgery
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What are the limitations of using filling pressures?
TEE is required to measure volume directly; filling pressures are surrogates
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What is the primary goal of goal-directed fluid therapy?
Optimize oxygen delivery
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What does the Frank-Starling mechanism describe?
Increased preload boosts cardiac output up to a plateau
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What happens with excessive volume in the heart?
Overstretches sarcomeres, fewer cross bridges, leading to reduced output
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What is the risk of both under- and over-resuscitation?
Can impair oxygen delivery
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What does reduced cross-bridges lead to?
Reduced output
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What is required to measure volume directly?
TEE (Transesophageal Echocardiography)
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What influences filling pressure?
Ventricular compliance, Filling pressure ≠ volume
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What conditions alter compliance?
Ischemia or hypertrophy
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What does contractility reflect?
Myocardium's ability to shorten and generate force
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Is contractility dependent on preload and afterload?
No, it is independent
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What happens to output with increased contractility?
Output increases
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What happens to output with decreased contractility?
Output decreases
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What does Starling's Law state?
↑ Preload → ↑ Contraction force
• This is NOT the same as increasing contractility
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Is increasing preload the same as increasing contractility? (Regarding Starling's Law)
No, they are not the same
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What is the goal of Goal-Directed Fluid Management?
Optimize patient’s position on the Starling Curve
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What do small fluid boluses help assess?
Preload dependence vs. independence (200–250 mL)
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What can fluid status do during surgery?
Shift rapidly
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What are dynamic indicators of preload responsiveness?
Pulse contour analysis, Esophageal Doppler
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What can a small bolus do in patients with poor cardiac function?
Shift from preload independence, lead to pulmonary edema
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What do patients on the lower part of the Starling curve experience?
Respond to fluid with increased sarcomere stretch
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What does enhanced stretch lead to?
More cross-bridge formation → greater cardiac output
• These patients are considered "volume responsive"
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What is the state of patients who are volume responsive?
Preload dependence, suitable candidates for fluid resuscitation
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What does the plateau region of the Starling curve indicate?
Optimal volume status
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What happens if more fluid is given during preload independence?
Unlikely to enhance cardiac output or oxygen delivery, excess fluid may be harmful, pushing the patient further along the curve and worsening outcomes
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What are the consequences of excessive preload?
Reduced myocardial efficiency, risk of pulmonary edema and congestive heart failure
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What is the blue zone on the Starling curve?

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What is the green zone on the Starling curve?

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What is the pink zone on the Starling curve?

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What does advanced monitoring enhance?
Assessment of fluid responsiveness, oxygen delivery, microcirculatory flow
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What do most monitoring devices use for calculations?
Arterial or SpO₂ waveforms
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What is pulse pressure variation derived from?
The arterial waveform
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What does pulse pressure variation measure?
Max and min pulse pressure across the respiratory cycle
Calculates the percentage change → used to guide fluid management
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What does pulse contour analysis assess?
Changes in stroke volume during the respiratory cycle
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What does pulse contour analysis assume about the patient?
Patient is on positive pressure ventilation (PPV)
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What does preload responsiveness assess?
Changes in stroke volume during the respiratory cycle
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How does intra-thoracic pressure affect stroke volume?
It changes stroke volume during positive pressure ventilation
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What does increased LV preload lead to?
Increased stroke volume via the Frank-Starling mechanism
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What happens to LV filling during expiration?
LV filling decreases due to reduced RV preload from prior cardiac cycles
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What is pulmonary transit time?
Delay in LV filling due to previous cardiac cycles
(Left ventricular (LV) filling decreases due to reduced right ventricular (RV) preload from prior cardiac cycles)
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What indicates a patient may need more fluid?
Greater stroke volume variation during the respiratory cycle, caused by changes in intrathoracic pressure affecting RV filling
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What fluid bolus increase indicates preload responsiveness?
200–250 mL increases stroke volume (SV) > 10%
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What pulse contour indices suggest volume responsiveness?
PVI, SVV, SPV, PPV suggest volume responsiveness when: Values greater than 13–15%
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What conditions affect pulse contour analysis accuracy? (limitations)
Spontaneous breathing, low tidal volumes, PEEP, open chest procedures, RV dysfunction, cardiac dysrhythmias
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What is the role of esophageal Doppler?
Point-of-care hemodynamic assessment, less invasive tool for fluid management
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How is the esophageal Doppler probe positioned?
Insert ~35 cm from incisors, aligns with T5–T6 or third sternocostal junction
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What does the esophageal Doppler measure?
Blood flow velocity and aortic diameter
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What are key points of esophageal Doppler waveform analysis?
Includes examples of waveform changes and interventions
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What conditions limit the accuracy of esophageal Doppler?
Aortic stenosis, insufficiency, thoracic aortic disease, aortic cross-clamping, CPB, pregnancy
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What indicates optimal fluid administration on the Starling curve?
SV increases by more than 10% after fluid bolus

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What should be done if SV changes by less than 10%?
Consider other measures like vasoactive drugs

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What is the origin of Enhanced Recovery After Surgery (ERAS)?
Originally developed for colon surgery
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What is the aim of ERAS programs?
To improve postsurgical outcomes through standardized perioperative care
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What are the core goals of ERAS?
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What is a key note on ERAS implementation?
Protocols vary by institution, but core elements are widely shared
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What is a notable guideline in ERAS?
Allowing clear fluids up to 2 hours before surgery
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What is the benefit of allowing clear fluids preoperatively?
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What is the risk associated with gastric pH < 2.5 and volume > 25 mL?
Risk of Mendelson syndrome
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What type of fluids are encouraged preoperatively (2 hours before)?
Carbohydrate-rich fluids (e.g., Gatorade)
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What are the benefits of carbohydrate-rich fluids before surgery?
Helps maintain glucose and insulin levels, blunts stress response, provides same benefits as clear fluids
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What should be ensured when using epidural anesthesia?
Lower extremity function must be intact
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What happens to the P50 curve during hypoxemia?
Shifts to the right, releases more O₂ to tissues
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Why is it important to ensure lower extremity function with epidural anesthesia?
It facilitates early ambulation, supporting faster recovery.
What is Mendelson syndrome associated with in terms of gastric pH and volume?
Gastric pH < 2.5 and volume > 25 mL or 0.4 mL/kg.
Why is esophageal disease (e.g., varices) a relative contraindication?
Because it increases the risk of traumatic esophageal injury.
What is the effect of reduced left ventricular (LV) preload on stroke volume?
Reduced LV preload leads to a decrease in stroke volume.
What causes restricted RV filling during positive pressure inspiration?
Pulmonary vein compression and increased pleural pressure.
How does positive pressure inspiration affect right ventricular (RV) filling?
It restricts right ventricular (RV) filling due to pulmonary vein compression and increased pleural pressure.
How does positive pressure inspiration affect left ventricular (LV) filling?
It enhances left ventricular (LV) filling.
What traditional indicators were once used to assess fluid balance, and what has replaced them?
Traditional indicators included heart rate, MAP (mean arterial pressure), and CVP (central venous pressure). These have been replaced by dynamic measures of fluid responsiveness.
How does surgery affect fluid retention?
ADH (antidiuretic hormone) is released during surgery, causing fluid retention for several days.
Treatment for non-gap acidosis
• Sodium bicarbonate is more commonly used
• Most causes involve bicarbonate loss
What is the treatment for Uremia/drug-induced metabolic acidosis?
Dialysis
What is the caution of NaHCO3 in intracellular acidosis?
Caution: NaHCO₃ may worsen intracellular acidosis if ventilation
or perfusion is inadequate
Relationship Between CO₂ Production and Ventilation (calculation)
PaCO₂ = CO₂ Production ÷ Alveolar Ventilation
What happens to the chloride shift in the lungs?
The chloride shift reverses—Cl⁻ exits erythrocytes as CO₂ is exhaled and HCO₃⁻ re-enters the cell.
What is the chloride (Hamburger) shift?
The chloride shift refers to Cl⁻ entering erythrocytes to maintain electrical neutrality as bicarbonate (HCO₃⁻) exits the cell. In the lungs, the shift reverses as CO₂ is exhaled.
How are hydrogen ions (H⁺) and bicarbonate ions (HCO₃⁻) buffered during gas exchange in the blood?
H⁺ is buffered by hemoglobin; HCO₃⁻ is transported into plasma as a buffer.
What is the normal total plasma magnesium level?
1.7–2.4 mg/dL (1.5–2.1 mEq/L)
What percentage of total body magnesium is found in extracellular fluid?
1% (0.3% in plasma)
Where is the majority of magnesium stored in the body?
Intracellularly (muscle and bone)
What does serum magnesium not reflect?
Total body magnesium stores
How does magnesium affect calcium's effects?
Counteracts calcium’s effects
What is magnesium essential for in the body?
DNA synthesis and enzymatic reactions
Why is magnesium critical for cardiac function?
It supports normal cardiac function
Where is most magnesium reabsorbed in the body?
In the renal tubules
What is the IV dosage for managing pre-eclampsia with magnesium?
4 g IV over 10–15 minutes, then 1 g/hr for 24 hours
What risk increases with magnesium use beyond 48 hours in pre-eclampsia?
Neonatal respiratory depression, hypotension, and lethargy (mag crosses placenta)
How does magnesium act as an opioid-sparing adjunct?
Through NMDA receptor antagonism
What condition is magnesium used to treat related to bronchospasm?
Acute bronchospasm
What cardiac rhythm disturbances can magnesium help manage?
Symptomatic PVCs and Torsades de pointes
What can hypermagnesemia enhance?
Neuromuscular blockade effects (succinylcholine and nondepolarizing agents)
What should be considered in preeclamptic patients receiving magnesium?
Caution with emergent C-sections
What is the normal blood pH range?
7.35 – 7.45
What is acidosis defined as?
pH < 7.35
What is alkalosis defined as?
pH > 7.45
What does the Henderson-Hasselbalch equation describe?
pH as a function of the ratio of [A⁻] to [HA]
What does pKa represent in the Henderson-Hasselbalch equation?
Negative log of the acid dissociation constant
What does [A⁻] represent in the equation?
Concentration of the conjugate base (e.g., bicarbonate HCO₃⁻)
What does [HA] represent in the equation?
Concentration of the weak acid (e.g., carbonic acid H₂CO₃)
What does PaCO₂ represent in the Henderson-Hasselbalch equation?
Partial pressure of CO₂ in arterial blood
What is the normal bicarbonate concentration ([HCO₃⁻])?
24 mEq/L
What is the normal PaCO₂ level?
40 mmHg
What is the pH of blood when substituting normal values into the Henderson-Hasselbalch equation?
7.4
What does the 0.03 in the Henderson-Hasselbalch equation refer to?
Solubility coefficient of CO₂ in plasma
Specifically: It represents how much dissolved CO₂ is present in blood plasma per mmHg of PCO₂.
What is the major by-product of aerobic metabolism?
CO₂, diffusing into capillary blood.
How is most CO₂ buffered in the blood?
A small amount dissolves in plasma.
What percentage of CO₂ is transported as bicarbonate?
70%
What percentage of CO₂ is bound to hemoglobin?
23%
What percentage of CO₂ is dissolved in plasma?
7%
How does venous blood PvCO₂ compare to arterial blood PaCO₂?
PvCO₂ is ~5 mmHg higher than PaCO₂.
What is the arterial pH?
7.40
What is the venous pH?
7.36
What is the Bohr effect?
Acidic environments enhance O₂ offloading from hemoglobin.
What is the Haldane effect?
Acidic environments increase CO₂ binding to hemoglobin.
How is CO₂ removed from the body?
Via alveolar ventilation.
What happens to pulmonary blood pH as CO₂ is eliminated?
It rises. This facilitates CO₂ offloading from hemoglobin.
What is the CO₂ transport reaction?
H₂O + CO₂ ⇌ H₂CO₃ ⇌ H⁺ + HCO₃⁻
What enzyme is essential for the CO₂ transport reaction?
Carbonic anhydrase.
Where is carbonic anhydrase found?
Inside RBCs, not in plasma.
What does carbonic anhydrase catalyze?
Formation of carbonic acid from H₂O and CO₂.
What does carbonic acid quickly dissociate into?
H⁺ and HCO₃⁻.
What maintains electrical neutrality in erythrocytes?
Cl⁻ enters erythrocytes (Chloride shift).
What happens to erythrocytes in venous circulation due to Cl⁻?
They swell, increasing venous hematocrit by ~3% higher than arterial hematocrit (swelling process reverses in the lungs).
What is the normal range for PaCO₂?
35 – 45 mmHg
What indicates a respiratory disorder?
pH and PaCO₂ move in opposite directions.
What indicates respiratory acidosis?
↓ pH, ↑ CO₂
What indicates respiratory alkalosis?
↑ pH, ↓ CO₂
What is the normal range for HCO₃⁻?
22 – 26 mEq/L
What indicates a metabolic disorder?
pH and HCO₃⁻ move in the same direction.
What indicates metabolic acidosis?
↓ pH, ↓ HCO₃⁻
What indicates metabolic alkalosis?
↑ pH, ↑ HCO₃⁻
What is the normal range for the anion gap?
8–12 mEq/L
What does the ROME mnemonic stand for?
Respiratory Opposite, Metabolic Equal.
What is full compensation?
pH is fully restored to normal.
What is partial compensation?
pH improves but remains outside the normal range.
What is respiratory compensation?
Rapid changes driven by ventilation. (respiratory compensation to the kidneys is slow)
What is metabolic compensation?
Slow changes due to altered H⁺ excretion by kidneys. (metabolic changes driven by changes in ventilation is fast)
What indicates a mixed disorder?
Suspect mixed if:
What should you check if PaO₂ is normal?
Calculate the A-a gradient to assess for a shunt.
What is the A-a gradient used for?
To assess for a shunt and its severity.
What causes respiratory acidosis?
• Occurs when alveolar ventilation cannot keep up with CO₂ production.
What is the treatment focus for respiratory acidosis?
Correcting the underlying cause.
When is mechanical ventilation indicated for respiratory acidosis?
If pH < 7.20.
What is hypercapnia?
PaCO₂ > 45 mmHg.
What is hypocapnia?
PaCO₂ < 35 mmHg.
How do kidneys compensate for respiratory acidosis?
How long does full compensation for respiratory acidosis take?
Several days.
What causes respiratory alkalosis?
Alveolar ventilation exceeds CO₂ production.
What are the common causes of respiratory alkalosis?
How do kidneys compensate for respiratory alkalosis?
Excrete bicarbonate (HCO₃⁻).
What is the primary goal in treating respiratory alkalosis?
Identify and correct the underlying cause.
What are the causes of metabolic acidosis?
What is the Anion Gap formula?
Anion Gap = Na⁺ - (Cl⁻ + HCO₃⁻)
• Helps identify the underlying cause of metabolic acidosis
What is the normal range for Anion Gap?
8–12 mEq/L.
What is the difference between gap and non-gap acidosis?
How does the body compensate for metabolic acidosis?
By increasing minute ventilation to eliminate CO₂.
What is the Respiratory Compensation Rule?
PaCO₂ decreases by 1–1.5 mmHg for every 1 mEq/L drop in HCO₃⁻.
When is sodium bicarbonate used in anion gap acidosis?
If pH < 7.2 and patient is hemodynamically unstable.
• Bicarbonate may help when acidosis impairs enzyme function
What is the treatment for lactic acidosis?
IVF, oxygen, cardiopulmonary support.
What is the treatment for DKA?
IVF, insulin.
What causes metabolic alkalosis?
How does the body compensate for metabolic alkalosis?
By retaining CO₂ through decreased ventilation.
How does PaCO₂ change with each 1 mEq/L rise in HCO₃⁻?
Increases by 0.5–1 mmHg for every 1 mEq/L rise in HCO₃⁻
What is the first step in treating metabolic alkalosis?
Address the underlying cause
What is acetazolamide used for in metabolic alkalosis?
Promotes renal bicarbonate excretion (carbonic anhydrase inhibitor)
What role does spironolactone play in metabolic alkalosis?
Acts as a mineralocorticoid antagonist
What is the treatment for severe or refractory cases of metabolic alkalosis?
Dialysis
What is the 4:2:1 Rule for fluid maintenance?
4 mL/kg/hr for first 10 kg of body weight, 2 mL/kg/hr for second 10 kg, 1 mL/kg/hr each kg thereafter 20 kg
for adults: body wt (kg) + 40 ml/hr
How do you calculate the estimated fluid deficit?
Fasting hours × Hourly maintenance rate
What is the fluid replacement for very minimal trauma?
1–2 mL/kg/hr
• e.g., Orofacial surgery
What is the fluid replacement for minimal trauma?
2–4 mL/kg/hr
• e.g., Inguinal hernia repair
What is the fluid replacement for moderate trauma?
4–6 mL/kg/hr
• e.g., Major nonabdominal surgery
What is the fluid replacement for severe trauma?
6–8 mL/kg/hr
• e.g., Major abdominal surgery
What is the crystalloid replacement ratio for blood loss?
3:1 (3 mL crystalloid per 1 mL blood lost)
What is the colloid/blood replacement ratio for blood loss?
1:1 (1 mL per 1 mL blood lost)
What is the maintenance IV fluid rate for a 17 kg patient?
What is the maintenance IV fluid rate for an 8 kg patient?
4 mL/kg/hr for the first 10 kg = 40 mlAnswer = 32 mL/hr
What is the maintenance IV fluid rate for a 120 kg patient?
Body weight (120 kg) + 40 mL
Answer = 160 mL/hr
What misconception existed about preoperative fasting?
Thought to cause dehydration, but intravascular volume remains mostly unaffected
• Patients can now drink clear fluids up to 2 hours before surgery
What is the issue with 'third space' fluid loss?
Minimal evidence supports its significance; may lead to excessive fluid administration
What is the current practice for blood loss replacement?
Guide replacement by fluid responsiveness
What was the historical approach to managing post-induction hypotension?
Managed with fluid, but often caused by vasodilation, better treated with vasopressors
Why is urine output unreliable during surgery?
ADH limits urine output, making it unreliable during surgery
What are the limitations of using filling pressures?
TEE is required to measure volume directly; filling pressures are surrogates
What is the primary goal of goal-directed fluid therapy?
Optimize oxygen delivery
What does the Frank-Starling mechanism describe?
Increased preload boosts cardiac output up to a plateau
What happens with excessive volume in the heart?
Overstretches sarcomeres, fewer cross bridges, leading to reduced output
What is the risk of both under- and over-resuscitation?
Can impair oxygen delivery
What does reduced cross-bridges lead to?
Reduced output
What is required to measure volume directly?
TEE (Transesophageal Echocardiography)
What influences filling pressure?
Ventricular compliance, Filling pressure ≠ volume
What conditions alter compliance?
Ischemia or hypertrophy
What does contractility reflect?
Myocardium's ability to shorten and generate force
Is contractility dependent on preload and afterload?
No, it is independent
What happens to output with increased contractility?
Output increases
What happens to output with decreased contractility?
Output decreases
What does Starling's Law state?
↑ Preload → ↑ Contraction force
• This is NOT the same as increasing contractility
Is increasing preload the same as increasing contractility? (Regarding Starling's Law)
No, they are not the same
What is the goal of Goal-Directed Fluid Management?
Optimize patient’s position on the Starling Curve
What do small fluid boluses help assess?
Preload dependence vs. independence (200–250 mL)
What can fluid status do during surgery?
Shift rapidly
What are dynamic indicators of preload responsiveness?
Pulse contour analysis, Esophageal Doppler
What can a small bolus do in patients with poor cardiac function?
Shift from preload independence, lead to pulmonary edema
What do patients on the lower part of the Starling curve experience?
Respond to fluid with increased sarcomere stretch
What does enhanced stretch lead to?
More cross-bridge formation → greater cardiac output
• These patients are considered "volume responsive"
What is the state of patients who are volume responsive?
Preload dependence, suitable candidates for fluid resuscitation
What does the plateau region of the Starling curve indicate?
Optimal volume status
What happens if more fluid is given during preload independence?
Unlikely to enhance cardiac output or oxygen delivery, excess fluid may be harmful, pushing the patient further along the curve and worsening outcomes
What are the consequences of excessive preload?
Reduced myocardial efficiency, risk of pulmonary edema and congestive heart failure
What is the blue zone on the Starling curve?

What is the green zone on the Starling curve?

What is the pink zone on the Starling curve?

What does advanced monitoring enhance?
Assessment of fluid responsiveness, oxygen delivery, microcirculatory flow
What do most monitoring devices use for calculations?
Arterial or SpO₂ waveforms
What is pulse pressure variation derived from?
The arterial waveform
What does pulse pressure variation measure?
Max and min pulse pressure across the respiratory cycle
Calculates the percentage change → used to guide fluid management
What does pulse contour analysis assess?
Changes in stroke volume during the respiratory cycle
What does pulse contour analysis assume about the patient?
Patient is on positive pressure ventilation (PPV)
What does preload responsiveness assess?
Changes in stroke volume during the respiratory cycle
How does intra-thoracic pressure affect stroke volume?
It changes stroke volume during positive pressure ventilation
What does increased LV preload lead to?
Increased stroke volume via the Frank-Starling mechanism
What happens to LV filling during expiration?
LV filling decreases due to reduced RV preload from prior cardiac cycles
What is pulmonary transit time?
Delay in LV filling due to previous cardiac cycles
(Left ventricular (LV) filling decreases due to reduced right ventricular (RV) preload from prior cardiac cycles)
What indicates a patient may need more fluid?
Greater stroke volume variation during the respiratory cycle, caused by changes in intrathoracic pressure affecting RV filling
What fluid bolus increase indicates preload responsiveness?
200–250 mL increases stroke volume (SV) > 10%
What pulse contour indices suggest volume responsiveness?
PVI, SVV, SPV, PPV suggest volume responsiveness when: Values greater than 13–15%
What conditions affect pulse contour analysis accuracy? (limitations)
Spontaneous breathing, low tidal volumes, PEEP, open chest procedures, RV dysfunction, cardiac dysrhythmias
What is the role of esophageal Doppler?
Point-of-care hemodynamic assessment, less invasive tool for fluid management
How is the esophageal Doppler probe positioned?
Insert ~35 cm from incisors, aligns with T5–T6 or third sternocostal junction
What does the esophageal Doppler measure?
Blood flow velocity and aortic diameter
What are key points of esophageal Doppler waveform analysis?
Includes examples of waveform changes and interventions
What conditions limit the accuracy of esophageal Doppler?
Aortic stenosis, insufficiency, thoracic aortic disease, aortic cross-clamping, CPB, pregnancy
What indicates optimal fluid administration on the Starling curve?
SV increases by more than 10% after fluid bolus

What should be done if SV changes by less than 10%?
Consider other measures like vasoactive drugs

What is the origin of Enhanced Recovery After Surgery (ERAS)?
Originally developed for colon surgery
What is the aim of ERAS programs?
To improve postsurgical outcomes through standardized perioperative care
What are the core goals of ERAS?
What is a key note on ERAS implementation?
Protocols vary by institution, but core elements are widely shared
What is a notable guideline in ERAS?
Allowing clear fluids up to 2 hours before surgery
What is the benefit of allowing clear fluids preoperatively?
What is the risk associated with gastric pH < 2.5 and volume > 25 mL?
Risk of Mendelson syndrome
What type of fluids are encouraged preoperatively (2 hours before)?
Carbohydrate-rich fluids (e.g., Gatorade)
What are the benefits of carbohydrate-rich fluids before surgery?
Helps maintain glucose and insulin levels, blunts stress response, provides same benefits as clear fluids
What should be ensured when using epidural anesthesia?
Lower extremity function must be intact
What happens to the P50 curve during hypoxemia?
Shifts to the right, releases more O₂ to tissues
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