Queste flashcard non sono ancora salvate — spariranno se lasci la pagina. Crea un account gratuito per conservarle e sbloccare tutto quello qui sotto.
What is an allergy?
A range of symptoms due to inappropriate activation of the immune system to benign substances.
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What are the ways the immune system can kill pathogens?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
Where are mast cells located?
Beneath the epithelial surface.
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What can mast cells do?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What triggers granule release in mast cells?
Secondary exposure to antigen causing crosslinking between IgE/ receptor on mast cell surface
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What are the components of mast cell granules?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What does histamine do?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What are the types of hypersensitivity reactions?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
How is IgE produced?
When Th2 cells instruct B cells to class switch into IgE plasma cells.
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What signals are needed for CD4⁺ T cell activation?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What cytokines drive T cell differentiation?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What is sensitization in allergy?
The presence of IgE antibodies to a particular substance.
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What does allergy testing detect?
Sensitization but does not prove the presence of allergy.
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What is skin prick testing used for?
To detect localized mast cell degranulation in the skin.
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What are reasons for positive SPT without clinical allergy?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What is atopy?
An inherited predisposition to develop IgE-mediated hypersensitivity to common environmental antigens.
Can be modified by environmental factor
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What components lead to IgE sensitization?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What are the cytokines produced by Th2 cells?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What occurs during the effector phase of Type I hypersensitivity?
Re-exposure to allergen causes IgE cross-linking on mast cells, leading to degranulation and mediator synthesis.
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
Define Type I hypersensitivity reactions.
Immediate hypersensitivity due to mast cell/basophil activation via IgE cross-linking.
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What are the phases of Type I hypersensitivity?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What occurs during the immediate reaction of Type I hypersensitivity?
Mast cell granule release: histamine, tryptase, proteases, heparin.
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What are the effects of histamine release during an immediate reaction?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What is involved in the late-phase reaction of Type I hypersensitivity?
Mast cells and Th2 cells release cytokines & chemokines, recruiting eosinophils and leukocytes.
Causing chronic inflammation and tissue damage
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What are some examples of Type I hypersensitivity?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What are localized reactions in IgE-mediated allergic reactions?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What is a systemic reaction in IgE-mediated allergic reactions?
Anaphylaxis: widespread degranulation causing hypotension, airway obstruction, angioedema, urticaria.
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What are the clinical signs of anaphylaxis?
Sfoglia le tue carte qui, oppure sign up to study with spaced repetition.
What is an allergy?
A range of symptoms due to inappropriate activation of the immune system to benign substances.
What are the ways the immune system can kill pathogens?
Where are mast cells located?
Beneath the epithelial surface.
What can mast cells do?
What triggers granule release in mast cells?
Secondary exposure to antigen causing crosslinking between IgE/ receptor on mast cell surface
What are the components of mast cell granules?
What does histamine do?
What are the types of hypersensitivity reactions?
How is IgE produced?
When Th2 cells instruct B cells to class switch into IgE plasma cells.
What signals are needed for CD4⁺ T cell activation?
What cytokines drive T cell differentiation?
What is sensitization in allergy?
The presence of IgE antibodies to a particular substance.
What does allergy testing detect?
Sensitization but does not prove the presence of allergy.
What is skin prick testing used for?
To detect localized mast cell degranulation in the skin.
What are reasons for positive SPT without clinical allergy?
What is atopy?
An inherited predisposition to develop IgE-mediated hypersensitivity to common environmental antigens.
Can be modified by environmental factor
What components lead to IgE sensitization?
What are the cytokines produced by Th2 cells?
What occurs during the effector phase of Type I hypersensitivity?
Re-exposure to allergen causes IgE cross-linking on mast cells, leading to degranulation and mediator synthesis.
Define Type I hypersensitivity reactions.
Immediate hypersensitivity due to mast cell/basophil activation via IgE cross-linking.
What are the phases of Type I hypersensitivity?
What occurs during the immediate reaction of Type I hypersensitivity?
Mast cell granule release: histamine, tryptase, proteases, heparin.
What are the effects of histamine release during an immediate reaction?
What is involved in the late-phase reaction of Type I hypersensitivity?
Mast cells and Th2 cells release cytokines & chemokines, recruiting eosinophils and leukocytes.
Causing chronic inflammation and tissue damage
What are some examples of Type I hypersensitivity?
What are localized reactions in IgE-mediated allergic reactions?
What is a systemic reaction in IgE-mediated allergic reactions?
Anaphylaxis: widespread degranulation causing hypotension, airway obstruction, angioedema, urticaria.
What are the clinical signs of anaphylaxis?
Sei sicuro di voler eliminare 0 flashcard? Questa azione non può essere annullata.
Seleziona i tag da rimuovere da 0 flashcard selezionata(e):
Caricamento tag...